Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives  

作　　者：Li Chen Wen Qiu Jia Tang Zhi Feng Wang Shu Ying He 

机构地区：[1]Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China [2]Tianjin Hankang Medicinal & Biological Technology Co., Ltd., Tianjin 300203, China [3]School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China

出　　处：《Chinese Chemical Letters》2011年第4期413-416,共4页中国化学快报（英文版）

基　　金：supported by a grant from the National Natural Science Foundation of China(No.2097210);research grants from the Natural Science Foundation of Jiangsu Province(No.BK2009302);Tianjin Application Bases and Advanced Technology Research Program Key Projects(No.JCZDJC21400)

摘　　要：A series of furoxan-based novel nitric oxide-donating ursolic acid（UA） derivatives（7a-f） were synthesized,and their cytotoxic activities against HepG2 cells in vitro were evaluated by MTT method.It was found that 7a-d and 7f showed more potent cytotoxic activities than control 5-fluorouracil and UA.A series of furoxan-based novel nitric oxide-donating ursolic acid（UA） derivatives（7a-f） were synthesized,and their cytotoxic activities against HepG2 cells in vitro were evaluated by MTT method.It was found that 7a-d and 7f showed more potent cytotoxic activities than control 5-fluorouracil and UA.

关 键 词：Ursolic acid Nitric oxide FUROXAN Cytotoxic activity 

分 类 号：TQ560.1[化学工程—炸药化工] S482.39[农业科学—农药学]