水杨醛甘氨酸Schiff碱铜配合物的合成、结构、磁性及其化学核酸酶活性研究  

Synthesis,Crystal Structure,Magnetic Properties,DNA Binding and Cleavage Activity of One Three-dimensional Glycine Schiff Base Copper(Ⅱ) Coordination Polymers

作　　者：高春艳[1] 冯莉[1,2] 卢静[1] 王志刚[1] 田金磊[1] 顾文[1] 阎世平[1] 

机构地区：[1]南开大学化学系,天津300071 [2]天津中医药大学科研处,天津300193

出　　处：《南开大学学报（自然科学版）》2011年第1期1-8,13,共9页Acta Scientiarum Naturalium Universitatis Nankaiensis

基　　金：国家自然科学基金(20771063;90922032)

摘　　要：合成了一个水杨醛甘氨酸Schiff碱铜配合物.X-射线单晶结构分析表明,铜离子通过配体羧基氧桥联形成一个三维的孔洞结构.采用电子吸收光谱、荧光光谱、电化学、凝胶电泳等方法,研究了配合物与DNA的相互作用.化学核酸酶作用机理研究表明,超氧阴离子自由基参与氧化断裂DNA反应.One glycine Schiff base copper（Ⅱ） complex[（CuL）_2]_n（H_2L is a Schiff-base ligand derived from the condensation reaction of N-（2-hydroxybenzaldehyde） and L-glycine,）, has been synthesized and characterized by single crystal X-ray differaction.The binding interactions of the complex with CT-DNA have been investigated by UV-visible spectra,fluorescence quenching method and cyclic voltammetry,which shows that the complex binds to CT-DNA with an intercalative mode.In addition,the DNA cleavage experiments have been also investigated by agarose gel electrophoresis.The complex shows oxidative DNA cleavage activity in the presence of H_2O_2/sodium ascorbate and the reactive oxygen species（ROS） responsible for the DNA cleavage is likely superoxide anion radical（·O_2^-）.

关 键 词：氨基酸Schiff碱 铜配合物 DNA切割 晶体结构 

分 类 号：O614.81[理学—无机化学]