冻干流行性乙型脑炎灭活疫苗(非洲绿猴肾细胞)和减毒活疫苗序贯免疫的安全性评价  

Safety Evaluation of Sequential Schedules Using Freeze-dried Japanese Encephalitis Inactivated Vaccine(Vero Cell)and Japanese Encephalitis Attenuated Live Vaccine

作　　者：李永成[1] 张之伦[1] 张颖[1] 张怡宾 高志刚[1] 陈德荣[3] 孙安悦 黄海涛[1] 孙静[1] 李晓静[5] 

机构地区：[1]天津市疾病预防控制中心,天津300011 [2]辽宁成大生物股份有限公司,沈阳116001 [3]天津市红桥区疾病预防控制中心,天津300132 [4]天津市东丽区疾病预防控制中心,天津300300 [5]天津市北辰区疾病预防控制中心,天津300400

出　　处：《中国疫苗和免疫》2011年第2期155-157,共3页Chinese Journal of Vaccines and Immunization

摘　　要：目的观察接种冻干流行性乙型脑炎(乙脑)灭活疫苗(非洲绿猴肾细胞)[Japanese Encephalitis Vaccine(Vero Cell),Inactivated,Freeze-dried;JEV-I]后的临床反应,以及和乙脑减毒活疫苗(Japanese Encephalitis Attenuated Live Vaccine;JEV-L)序贯免疫程序的安全性。方法以9月龄和2岁健康儿童为观察对象,分三种组合接种JEV,采取主动和被动监测相结合的方式观察接种后30d内的临床反应。结果 JEV-I和JEV-L的不良反应发生率分别为9.72%和9.59%,差异无统计学意义(χ2=0.024,P=0.876)。不良反应以Ⅰ级反应为主,占82.25%;需要治疗的发热反应占0.83%,未出现严重不良反应。三种免疫组合的不良反应发生率分别为10.50%、8.11%、9.59%,差异无统计学意义(χ2=4.267,P=0.118)。结论 JEV-I和JEV-L的不良反应发生率差异无统计学意义,JEV-I和JEV-L序贯免疫有良好的安全性。Objection To observe the clinical reaction of Freeze-dried Japanese Encephalitis Inactivated Vaccine （Vero Cell, JEV-I） and the safety of sequential schedules of two kinds of JEV. Method 9 months and 2 years old healthy children were selected as the study objects, using three types of combination with two kinds of JEV for immunization. Active and passive surveillance to observe the clinical reaction after 30 days of immunization. Result The rate of adverse reaction of JEV-I was 9.72%, the JEV-L was 9.59% （χ2=0.024, P=0.876）. The first level adverse reaction was 82.25%. The adverse reaction which need to be treated was 0.83 %, there was no serious adverse reaction. The rates of adverse reaction of three kinds of immunization are 10.50 %, 8.11% and 9.59 % respectively （χ2=4.267, P=0.118）. Conclusion The rates of adverse reaction have no difference between the JEV-I and the JEV-L. The kinds of sequential schedules of two kinds of JEV have good safety.

关 键 词：冻干流行性乙型脑炎灭活疫苗(非洲绿猴肾细胞) 流行性乙型脑炎减毒活疫苗 序贯免疫 安全性 

分 类 号：R186[医药卫生—流行病学] R512.32[医药卫生—公共卫生与预防医学]