幽门螺杆菌感染与急性冠脉综合征的关系  

The Relation between Helicobacter Pylori Infection and Acute Coronary Syndrome

作　　者：李龙学[1] 

机构地区：[1]中山大学附属第六医院呼吸内科,广州市510655

出　　处：《广西医学》2011年第3期288-290,共3页Guangxi Medical Journal

摘　　要：目的探讨幽门螺杆菌(Hp)感染与急性冠脉综合征(ACS)的关系。方法 ACS患者106例,其中AMI 57例,UAP 49例;可疑冠心病对照组61例,用酶联免疫吸附法(ELISA)测定血清幽门螺杆菌特异性抗体IgG(HpIgG)及白细胞介素-6(IL-6),用散射比浊法测定超敏C反应蛋白(hsCRP),用血液凝固法测定纤维蛋白原(FIB)水平。结果急性心肌梗死(AMI)组及不稳定型心绞痛(UAP)组血清HpIgG阳性率均显著高于对照组(P<0.01);Hp感染与ACS患者年龄、性别、糖尿病、肥胖、高血压、吸烟史及家族史等危险因素无关(P>0.05);ACS患者中HpIgG(+)组hsCRP、IL-6、FIB水平均明显高于HpIgG(-)组(P均<0.05)。结论 Hp感染与ACS相关,Hp感染可能通过促进IL-6、FIB及hsCRP水平而起作用。Objective To examine the relation between HP infection and acute coronary syndrome（ACS）.Methods HPIgG were measured in total 106 cases of ACS（acute myocardial infarction 57 cases,unstable angina pectoris 49 cases）and 61 normal controls by ELISA,through which HP Infection can be diagnosed.High sensitivity C-reactive protein（hsCRP）,fibrinogen（FIB）,interleukin-6（IL-6）were measured in 106 cases of ACS.Results The rate of seropositive for HPIgG in acute myocardial infarction group and unstable angina pectoris group was significantly higher than that of controls（P0.01）;these was no correlation between HP infection and hypertension,diabetes mellitus,obesity,smoking,age,gender and family medical history;the level of hsCRP in these of HPIgG seropositivity in ACS group was considerably higher than that of HPIgG seronegative in ACS group（P0.05）;the level of IL-6 and FIB in these of HPIgG seropositivity in ACS group was apparently higher than that of HPIgG seronegative in ACS group（P0.05）.Conclusion There is certain relation between HP infection and acute coronary syndrome.HP infection may act though raising the level of hsCRP,IL-6 and FIB.

关 键 词：急性冠脉综合征 幽门螺杆菌 白细胞介素-6 超敏C反应蛋白 纤维蛋白原 

分 类 号：R543.3[医药卫生—心血管疾病]