注射用盐酸伊立替康局部用药毒性研究  

On the toxicity of local administration of irinotecan hydrochloride for injection

作　　者：唐丽娟[1] 杨解人[1] 杨慧[1] 陈国祥[1] 

机构地区：[1]皖南医学院药理学教研室,安徽芜湖241002

出　　处：《皖南医学院学报》2011年第2期109-111,共3页Journal of Wannan Medical College

摘　　要：目的:观察注射用盐酸伊立替康溶血和凝集、局部血管刺激性及致过敏作用。方法:采用家兔红细胞悬液致溶血和凝集试验、家兔耳缘静脉局部血管刺激性试验及豚鼠全身主动过敏试验。结果:注射用盐酸伊立替康未见致溶血及致凝集作用;对家兔耳缘静脉注射无明显刺激反应;豚鼠致敏试验静脉用药2 h内未见全身主动过敏反应。结论:动物实验表明,盐酸伊立替康用于注射给药是安全可靠的。Objective：To observe the hemolysis and agglutination,local vascular irritation and allergenic effect of irinotecan hydrochloride injection.Methods：Determination of hemolysis and agglutination was conducted with red cell suspension,the local vascular irritation was performed in rabbits through intravenous drip of irinotecan hydrochloride and systemic active anaphylaxis was carried out in guinea-pigs.Results：Intervention with irinotecan hydrochloride caused hardly hemolysis and agglutination,and induced no stimulus response in the ear vein of the rabbits and systemic active anaphylaxis in the guinea-pigs in 2 hours as well.Conclusion：The experiments on animals show that irinotecan hydrochloride is safe for intravascular injection.

关 键 词：注射用盐酸伊立替康 溶血 凝集 局部血管刺激性 致过敏 

分 类 号：R979.1[医药卫生—药品]