斑点追踪成像评估心力衰竭兔左心室扭转和解旋  

Evaluation of left ventricular twist in rabbit model with heart failure by speckle tracking imaging

作　　者：李楠[1] 靳忠民[3] 任卫东[2] 杨军[1] 

机构地区：[1]中国医科大学附属第一医院心功能科,沈阳110001 [2]中国医科大学附属盛京医院超声科 [3]沈阳市第四人民医院

出　　处：《中华超声影像学杂志》2011年第3期253-257,共5页Chinese Journal of Ultrasonography

摘　　要：目的应用斑点追踪显像（STI）技术评价舒张性心力衰竭（DHF）和收缩性心力衰竭（SHF）兔模型的左室扭转及解旋运动的特点。方法33只雄性新西兰兔分为三组：分别为DHF模型组（12只）、SHF模型组（11只）及对照组（10只）。应用STI技术评估左室扭转，并行左室导管及心肌病理学检查。结果与对照组相比，DHF组左室峰值扭转角度（Ptw）无显著变化（P〉0．05），SHF组Ptw减低，两组的解旋均延迟，等容解旋率减低，DHF组的左室解旋峰速（PUTV）增加，SHF组的PuTV减低（P〈0．05）。两组的Ptw均与左室收缩功能指标呈正相关。SHF组的PuTV与左室导管舒张功能指标呈正相关。结论STI可有效评价SHF和DHF兔左室扭转和解旋运动。Objective To assess left ventricular twist and untwist in rabbit models with diastolic heart failure（DHF） and systolic heart failure（SHF） by speckle tracking imaging（STI）. Methods Thirty- three male New Zealand rabbits were divided into three groups：one group was used to establish DHF model by suprarenal abdominal aortic constriction（ n = 12） and the other was used to establish SHF model by abdominal aortic constriction subdiaphragmly above celiac artery origin（ n = 11）, another was control group established by sham operation（ n = 10）. After two weeks, left ventricular twist-related parameters were measured, by STE. Finallly, left ventricular catheterization and myocardial pathological examination were performed. Results Compared with control group,peak twist angle （Ptw） and peak twisting velocity（PTV） remained unchanged in DHF group （ P 〉 0.05） and decreased in SHF group （ P 〈 0.05）. Isovolumic untwisting rate （IUR） decreased, untwisting half-time（UHT） was prolonged, time to peak twist （tPtw） and peak untwisting velocity（tPUTV）were delayed in SHF and DHF groups. In additon, Peak untwisting velocity（PUTV） decreased in SHF group, but increased in DHF group（ P 〈0.05）. Ptw correlated correlated positively with LVEF, ＋ dp/dtmax significantly in both groups （DHF group： r = 0. 897, P = 0. 002; r = 0. 719, P = 0. 044;SHF group： r = 0. 727, P = 0. 041; r = 0. 780, P = 0. 022）. A significantly positive correlation was observed between PUTV and - dp/dt Tau,LVEDP（ r = 0. 801, P = 0. 0173 r = 0. 814, P = 0. 014; r = 0. 875, P = 0. 004） in SHF group. Conclusions STI is useful in evaluating left ventricular twist and untwist in rabbit model of DHF and SHF.

关 键 词：超声心动描记术 心力衰竭 充血性 扭转 斑点追踪显像 

分 类 号：R445.1[医药卫生—影像医学与核医学]