温敏型壳聚糖介入核素^(188)Re内照射抗小鼠移植性肝癌(H_(22))  

Invistagation of antitumor efffect of internal Irradiation of Interventional Radionuclide ^(188)Re in Thermosensitive Chitosan on Mouse Transplanted Tumor H_(22)

作　　者：董峰[1] 郭红云[2] 张永东[2] 梅澍[1] 

机构地区：[1]甘肃省肿瘤医院核医学科,兰州730050 [2]甘肃省医学科学研究院药理毒理研究中心,兰州730050

出　　处：《中国比较医学杂志》2011年第3期14-17,80,共5页Chinese Journal of Comparative Medicine

基　　金：2004年度<西部之光>资助项目;甘肃省科学事业项目(QS-041-C33-37)

摘　　要：目的研究温敏型壳聚糖(chitonsan CS)介入核素188Re内照射对小鼠移植性肝癌(H22)的抑制作用。方法建立小鼠肝癌(H22)模型后随机分成7组,即模型对照组、188Re(0.1mCi)组、188Re-S(0.1mCi)组、188Re+CS(0.1mCi)组、188 Re+CS(0.2mCi)组、188 Re+硫胶体+壳聚糖(188 Re-S+CS 0.1mCi)组和188 Re-S+CS(0.2mCi)组。各组动物瘤内分别注射相应试药,测定肿瘤抑制率。结果 188Re+CS组和188Re-S+CS组肿瘤生长速度减慢,肿瘤生长延迟,肿瘤抑制率在治疗后6 d最高,抑制率分别为67.35%和67.81%。结论温敏型壳聚糖介入核素188Re内照射对小鼠肝癌(H22)具有一定的抑制作用。Objectives To study the inhibitory activity of internal irradiation of interventional radionuclide 188Re in thermosensitive chitosan on mouse transplanted tumor H22（liver cancer）.Method The tumor-bearing mice were divided into 7 groups randomly,including model control,188 Re（0.1mCi） group,188 Re-S（0.1mCi） group,188 Re ＋ CS（0.1mCi） group,188 Re ＋ CS（0.2mCi）group,188 Re-S ＋ CS 0.1mCi）and188 Re-S ＋ CS（0.2mCi）group.The mice tumor was injected with corresponding reagent respectively,and the inhibitoy rate of tumor was observed after administrated.Results The growth of tumors in 188 Re ＋ CS group and 188 Re-S ＋ CS group was slowed.the tumor inhibitory rate reached the highest level after 6 days therapy,which respectively was 67.35% and 67.81%.Conclusions Internal irradiation of interventional radionuclide 188 Re in thermosensitive chitosan had the effect of inhibitory mice liver cancer.

关 键 词：188Re 温敏型壳聚糖 内照射 H22 抗肿瘤 

分 类 号：R817.91[医药卫生—影像医学与核医学] R332[医药卫生—放射医学]