通城移植毛喉鞘蕊花化学成分及抗肿瘤活性研究  

Studies on the Chemical Constituents of Coleus forskohlii Transplanted in Tongcheng and Their Antitumor Activity

作　　者：黄德红[1] 杨艳芳[2] 艾伦强[2] 陆毅[2] 吴和珍[2] 

机构地区：[1]湖北省襄樊市中医医院,湖北襄樊441000 [2]湖北中医药大学省部共建中药资源与中药复方教育部重点实验室,湖北武汉430065

出　　处：《中药材》2011年第3期375-378,共4页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金资助项目(30570187)

摘　　要：目的:研究通城移植毛喉鞘蕊花全草的化学成分。方法:利用硅胶柱色谱、制备薄层色谱和ToyopearlHW-40F凝胶渗透进行分离、纯化。根据理化性质和现代波谱技术并辅以化学方法进行结构鉴定。结果:从通城移植毛喉鞘蕊花中分离得到7个化合物,分别鉴定为:羽扇豆醇(1)、齐墩果酸(2)、熊果醇(3)、β-谷甾醇(4)、colonicacid(5)、去甲基柳杉树脂酚(6)、coleolic acid(7)。抗肿瘤实验结果表明化合物1、2、6、7均具有抗肿瘤活性。结论:化合物1、3为首次从该属植物中得到;化合物1为首次从该植物中发现的抗肿瘤活性成分。Objective：To study the chemical constituents of Coleus forskohlii.Methods：Isolation and purification were carried out by silica gel column chromatographic and Toyopearl HW-40F.Compounds were identified and elucidated by spectral and chemical methods.Results：Seven compounds were obtained from ethyl acetate extract fraction.Their structures were identified as lupeol（1）,oleanolic acid（2）,uvalo（3）,β-sitosterol（4）,colonic acid（5）,demethylcryptojaponol（6）,coleolic acid（7）.Compounds 1,2,6,7 showed obviously antitumor activity.Conclusion：Compound 1 and 3 are isolated from the genus for the first time.Moreover,compound 1 is firstly found to have antitumor activity from the plants.

关 键 词：毛喉鞘蕊花 化学成分 抗肿瘤活性 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]