当归四逆汤中肉桂酸及甘草酸在大鼠血清中含量测定及药动学研究  

Determination of Cinnamic Acid and Glycyrrhizic Acid in Rat Serum and its Pharmacokinetics after Oral Administration of Dangguisini Decoction

作　　者：高宇勤[1] 吴杰[2] 江仁望[2] 赵国平[1] 

机构地区：[1]暨南大学医学院,广东广州510632 [2]暨南大学药学院,广东广州510632

出　　处：《中药材》2011年第3期408-411,共4页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金(基金编号:30672679);十一五国家科技支撑计划(2007BA110B06-06)

摘　　要：目的:测定大鼠灌胃当归四逆汤后血清中肉桂酸、甘草酸血药浓度及药代动力学参数。方法:利用高效液相色谱(HPLC)法测定大鼠血清中肉桂酸、甘草酸血药浓度,应用3P97软件计算药代动力学参数。结果:大鼠口服当归四逆汤后肉桂酸药代动力学参数为Cmax9.2008(mg/L),AUC 304.0734(mg/L).min,甘草酸药代动力学参数为Cmax51.1330(mg/L),AUC 21476.9688(mg/L).min。结论:大鼠口服当归四逆汤后肉桂酸吸收快,代谢也较快;而甘草酸吸收快,但代谢相对较慢。Objective：To mensurate concentrations and pharmacokinetics of cinnamic acid and glycyrrhizic acid in rats after oral adiministration Dangguisini decoction.Methods： To Determine serum concentration of cinnamic acid and glycyrrhizic acid by High-Performance Liquid Chromatography and calculate its parameter of pharmacokinetics in rats after oral administration of Dangguisini decoction via 3P97 software.Results： Parameters of Pharmacokinetics of cinnamic acid and glycyrrhizic acid were Cmax 9.2008（mg/L）,AUC 304.0734（mg/L）·min and Cmax51.1330（mg/L）,AUC 21476.9688（mg/L）·min respectively in rats after oral administration of Dangguisini decoction.Conclusion： Absorption of cinnamic acid is quick and its metabolize is quick too,but metabolism of glycyrrhizic acid is oppositely slow in rats after oral administration of Dangguisini decoction.

关 键 词：肉桂酸 甘草酸 药代动力学 高效液相色谱 当归四逆汤 

分 类 号：R285.5[医药卫生—中药学]