急性心肌梗死患者早期检测血管内皮细胞蛋白C受体和脂联素的临床意义  

Clinical significance of early detection of vascular endothelial cell protein C receptor and adiponectin in the patients with acute myocardial infarction

作　　者：桑圣刚[1] 荣红[2] 

机构地区：[1]海南医学院临床检验学教研室,海口570102 [2]海南医学院附属医院口腔科

出　　处：《中国急救医学》2011年第4期307-309,共3页Chinese Journal of Critical Care Medicine

基　　金：基金项目：海南省自然科学基金项目（No.808234）

摘　　要：目的 探讨急性心肌梗死（AMI） 患者早期血管内皮细胞蛋白C受体（endothelial cell protein C receptor,EPCR）和脂联素（adiponectin,APN）的水平变化及临床意义.方法 AMI患者分别于6 h内、12 h采血,采用酶联免疫法测定52例AMI患者和70例健康对照者血浆EPCR和APN水平,采用全自动生化分析仪测定血清肌红蛋白（Mb）和肌钙蛋白T水平.结果 AMI组EPCR水平在6 h内显著升高,12 h急剧升高,与对照组比较差异有统计学意义（P〈0.05,P〈0.01）.AMI组APN水平在6 h内显著降低,12 h急剧降低,与对照组比较差异有统计学意义（P〈0.05,P〈0.01）,12 h与6 h内APN水平比较差异亦有统计学意义（P〈0.01）.AMI组APN水平与Mb水平呈负相关（r=-0.73,P〈0.05）.结论 早期联合检测EPCR和APN有利于对AMI患者血管内皮细胞损伤和心肌坏死程度的评估.Objective To observe plasma vascular endothelial cell protein C receptor （EPCR） and adiponectin （APN） levels, and to explore the clinical significance of combined detection in the patients with acute myocardial infarction （AMI）. Methods The level of EPCR and APN were determined by enzyme - linked immunosorbent assay in 52 AMI patients and 70 healthy cases of control group. Results There was significant difference in plasma EPCR levels between less than 6 h AMI group and control group （ P 〈 0.05 ） ; the level of EPCR was significantly higher in 12 h AMI group than in control group （P 〈 0.01 ）. As compared with control group, the level of APN was significantly lower in less than 6 h group （P 〈0.05）. The level of APN was significantly lower in 12 h AMI group than in less than 6 h AMI group （P 〈 0.01 ） ; As compared with control group, the level of APN was significantly lower in 12 h AMI group （ P 〈 0. 01 ）. By linear correlation analysis showed APN was a negative correlation with Mb （ r = - 0.73, P 〈 0.05 ）. Conclusion EPCR and APN were independent risk factor in AMI incident. Early combined monitoring of the EPCR and APN levels was favorable for evaluating the extent of myocardial necrosis and the prediction of vascular endothelial cell injury.

关 键 词：急性心肌梗死(AMI) 内皮细胞蛋白C受体 脂联素(APN) 

分 类 号：R392.11[医药卫生—免疫学]