疑似人粒细胞无形体病12例分析  

SUSPECTED HUMAN GRANULOCYTIC ANAPLASMOSIS:AN ANALYSIS OF 12 CASES

作　　者：王婷[1] 边城[1] 刘涵云[1] 黄德瑜[1] 李晓宇[1] 王慧[1] 

机构地区：[1]青岛大学医学院附属医院,山东青岛266003

出　　处：《齐鲁医学杂志》2011年第3期257-258,260,共3页Medical Journal of Qilu

摘　　要：目的研究人粒细胞无形体病疑似病例的流行病学和临床特点。方法回顾性分析12例人粒细胞无形体病疑似病例的临床资料。结果本组人粒细胞无形体病疑似病例流行地区位于胶东半岛地区,病人均为农民,年龄中位数为57岁,其中2例在起病前1周有明确蜱咬史。常见症状包括发热、腹泻、恶心等,并发症有出血、中毒性脑病、急性肾衰竭等,常见实验室检查指标异常有白细胞、血小板减少,转氨酶升高,尿蛋白、尿潜血,9例行人粒细胞无形体套式PCR检测均为阴性。经过抗生素和对症支持治疗痊愈11例,死亡1例。结论人粒细胞无形体病是一种蜱传急性自然疫源性疾病,可累及多脏器,高龄及有并发症病人易发生严重并发症,预后较差。Objective To investigate epidemiological and clinical features of suspected human granulocytic anaplasmosis（HGA）. Methods The clinical data of 12 suspected cases of HGA were analyzed retrospectively. Results The suspected cases in this review were found in Shandong Peninsula,all were farmers,with median age of 57 years.Of whom,two had an evident history of tick bite one week before the onset.Fever,diarrhea and nausea were the common symptoms.The complications included hemorrhage,toxic encephalopathy,acute renal failure,and so on.Leucopenia,thrombocytopenia,increase of aminotransferases,proteinuria and hematuria were the common abnormalities of laboratory findings.Nine cases underwent nested PCR detection for HGA were negative.Eleven patients recovered after antibiotics and supportive treatments;one died. Conclusion Human granulocytic anaplasmosis is an acute tick-borne zoonosis,which may involve multiple organs.The prognosis is poor in the aged and those with severe complications.

关 键 词：无形体科感染 蜱传播疾病 流行病学 预后 

分 类 号：R531.8[医药卫生—内科学]