心脏性猝死心肌组织HIF-1α和Bax表达及其相关性  

THE EXPRESSIONS OF HIF-1α AND Bax AND THEIR CORRELATION IN SUDDEN CARDIAC DEATH

作　　者：刘德衍[1] 袁磊[2] 杨彦华[3] 纪萍[3] 于建宪[3] 张七一[4] 林梅[1] 

机构地区：[1]青岛大学医学院附属青岛市市立医院病理科,山东青岛266021 [2]聊城市第二人民医院肾内科 [3]青岛市市立医院病理科 [4]青岛市市立医院心内科

出　　处：《青岛大学医学院学报》2011年第3期200-203,共4页Acta Academiae Medicinae Qingdao Universitatis

基　　金：青岛市科技发展计划立项项目(05-2-NS-43)

摘　　要：目的探讨缺氧诱导因子1 alpha(HIF-1α)和Bax蛋白在心脏性猝死(SCD)者心肌组织中的表达与相关性,并为法医学鉴定SCD提供客观依据。方法应用免疫组织化学方法,检测25例SCD者心肌组织中HIF-1α和Bax蛋白的表达,并以25例非SCD者心肌组织作为对照。结果 SCD者心肌组织HIF-1α与Bax的表达明显高于对照组(uc=6.083、5.573,P<0.01)。在SCD心肌组织中,HIF-1α表达与Bax表达呈正相关(r=0.736,P<0.01)。结论 HIF-1α与Bax表达的增高与SCD的发生有一定的相关性,HIF-1α与Bax可望作为诊断SCD较为客观的病理形态学指标。Objective To investigate the expressions of hypoxia-inducible factor-1 alpha（HIF-1α） and Bcl-2 associated X protein（Bax） and their correlation in myocardium of sudden cardiac death（SCD） and provide an objective evidence for forensicidentification.Methods The expressions of HIF-1α and Bax in myocardium of 25 SCD were detected using immunohistochemical technique,and 25 of non-sudden cardiac death served as controls.Results The expressions of HIF-1α and Bax in myocardium of the SCD were significantly higher than that of the control（Uc=6.083,5.573;P0.01）,and the expressions were positively correlated（r=0.736,P0.01）.Conclusion The elevation of the expressions of HIF-1α and Bax is associated with SCD to a certain extent.The HIF-1α and Bax will hopefully become a relatively objective pathomorphologic index in the diagnosis of SCD.

关 键 词：猝死 心脏 法医学 缺氧诱导因子1 Α亚基 BAX蛋白 免疫组织化学 细胞凋亡 

分 类 号：R541[医药卫生—心血管疾病]