不同β_2受体激动剂及吸入装置对支气管舒张试验的影响  

The effects of different β_2-receptor agonists and methods of inhalation in bronchodilation test

作　　者：吴龙云[1] 

机构地区：[1]安徽省蚌埠市第三人民医院呼吸内科肺功能室,233000

出　　处：《蚌埠医学院学报》2011年第4期356-358,共3页Journal of Bengbu Medical College

摘　　要：目的:比较2种β2受体激动剂以及不同吸入装置对支气管舒张试验结果的影响。方法:100例支气管哮喘患者吸药前均测定基础肺功能(FEV1)后随机分3组,A组30例用压力定量气雾吸入器(PMDI)吸入特布他林,B组30例用PMDI吸入沙丁胺醇,C组40例用储雾罐吸入特布他林,15 min后复测肺功能,分别计算FEV1改善率和增加绝对值以及支气管舒张试验阳性率。结果:A组和B组FEV1改善率和绝对值及舒张试验阳性率比较,差异无统计学意义(P>0.05);C组FEV1改善率和绝对值及舒张试验阳性率均高于A组和B组(P<0.01)。结论:特布他林和沙丁胺醇对支气管舒张试验的作用相似;使用储雾罐吸药,效果优于PMDI,可以增加吸药效率,提高支气管舒张试验阳性检出率,减少支气管哮喘的漏诊。Objective：To compare the effects of two kinds of β2-receptor agonists and different inhalation devices on the result of bronchodilatation testing.Methods：One hundred patients with bronchial asthma were divided into 3 groups：30 patients in group A inhaled terbutaline aerosol via PMDI,30 patients in group B inhaled salbutamol aerosol via PMDI,and 40 patients in group C inhaled terbutaline aerosol by spacer.The pulmonary function was checked after 15 minutes;the improving rate,the increased absolute value and the positive rate of bronchodilatation were calculated.Results：As for the improving rate,the absolute value and the positive rate of FEV1,no differences were detected in Group A and Group B（P0.05）;in Group C the above three rates were averagely higher than those in Group A and B,and the difference was significant（P0.01）.Conclusions：The comparative study shows that the effects of two short acting β2-receptor agonists are similar to salbutamol in bronchodilatation testing;the effect of inhaling by spacer is better than by PMDI,as it can increase the absorption factor,enhance the positive rate of bronchodilatation and reduce the missed diagnosis of bronchial asthma.

关 键 词：哮喘 呼吸功能试验 支气管舒张试验 气雾剂 特布他林 沙丁胺醇 

分 类 号：R562[医药卫生—呼吸系统]