炎症标志物与冠状动脉旁路移植和心脏瓣膜置换手术后心房颤动关系的Meta分析  

Meta analysis on relationship between inflammation marker and postoperative atrial fibrillation of patients after accepting coronary bypass grafting or cardiac valve replacement

作　　者：陶文艳[1] 沈冬焱 吴瑛[1] 肖倩[1] 吴芳琴[1] 唐泓源[1] 赵海波[3] 张海泳[3] 

机构地区：[1]首都医科大学护理学院 [2]健宫医院 [3]首都医科大学附属北京朝阳医院

出　　处：《护理研究（上旬版）》2011年第1期14-19,共6页Chinese Nursing Researsh

基　　金：国家自然科学基金面上项目“冠状动脉旁路移植术后心房炎症在术后房颤发生和维持中的作用及机制”,项目编号:30871049

摘　　要：[目的]通过Meta分析综合评价炎性标志物白细胞计数、C-反应蛋白、白细胞介素-6(IL-6)与冠状动脉旁路移植和心脏瓣膜置换手术后心房颤动的关系。[方法]制定原始文献的纳入标准、排除标准及检索策略,检索多个中英文数据库,对检索的文献进行质量评价后,应用RevMan4.3分析软件进行数据分析,并采用固定效应或随机效应模型计算合并后的综合效应。[结果]10篇文献符合纳入及排除标准。Meta分析结果表明,手术后心房颤动组术后白细胞计数及IL-6水平高于非心房颤动组,加权均方差(WMD)分别为1.97、203.43。[结论]术后白细胞计数及IL-6水平的增加与术后心房颤动的发生密切相关,提示由手术引发的炎症反应可能参与了术后心房颤动的发生和维持。Objective：To evaluate in comprehensive the relationship between inflammation markers including white blood cell（WBC） counts,C-reactive protein and interleukin-6（IL-6） and postoperative atrial fibrillation of patients after accepting coronary bypass grafting or cardiac valve replacement through meta-analysis.Methods： Enrollment and rule-out criteria and retrieval strategies for primitive literatures had been worked out.Several Chinese-English databases had been searched.All related studies had been carried out quality evaluation.Then all data were analyzed by adopting RevMan 4.3 software.And comprehensive effects after combination were calculated by adopting fix effect or random effect model.Results： Totally 10 studies met to the enrollment and rule-out criteria were finally analyzed.Both WBC counts and IL-6 level of patients with postoperative atrial fibrillation were higher than that of those without postoperative atrial fibrillation.Weighted mean differences of WBC counts and IL-6 levels were 1.97 and 203.43.Conclusion：Meta analysis showed postoperative enhanced WBC counts and IL-6 levels in patients were closely related with the occurrence of postoperative atrial fibrillation.It indicated that operation itself induced inflammatory reaction may participate the occurrence and maintainance of postoperative atrial fibrillation of patients.

关 键 词：炎性标志物 冠状动脉旁路移植术 瓣膜置换术 心房颤动 META分析 

分 类 号：R654.2[医药卫生—外科学]