8-iso-PGF2α及hs-CRP水平与2型糖尿病肾病关系  

RELATIONSHIP OF THE SERUM LEVEL OF 8-iso-PROSTAGLANDIN F2α AND HIGH SENSITIVE C-REACTIVE PROTEIN WITH TYPE 2 DIABETIC NEPHROPATHY

作　　者：韦涌涛[1] 王松霞[1] 李武伦[1] 

机构地区：[1]青岛市第八人民医院,山东青岛266100

出　　处：《青岛大学医学院学报》2011年第2期135-136,140,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨血清8-异前列腺素F2α（8-iso-PGF2α）及超敏C反应蛋白（hs-CRP）水平与2型糖尿病（T2DM）肾病的关系。方法 91例T2DM病人根据24 h尿微量清蛋白排泄率（UAER）分为3个亚组：无蛋白尿组（UAER〈20μg/min）、微量蛋白尿组（UAER 20~200μg/min）及大量蛋白尿组（UAER〉200μg/min）,另选择15例健康体检人员作为健康对照组。所有受检者血清8-iso-PGF2α检测采用ELISA法,hs-CRP检测采用免疫散射比浊法。结果糖尿病各亚组病人血清8-iso-PGF2α及hs-CRP水平均较健康对照组高,差异有统计学意义（F=59.82、57.49,q=8.16~17.92,P〈0.01）;无蛋白尿组、微量蛋白尿组及大量蛋白尿组病人血清8-iso-PGF2α及hs-CRP水平逐渐升高,差异有统计学意义（q=8.57~15.47,P〈0.01）。结论血清8-iso-PGF2α及hs-CRP的水平变化与T2DM肾病的发展密切相关。Objective To study the association of serum levels of 8-iso-prostaglandin F2α（8-iso-PGF2α） and high sensitive C-reactive protein（hs-CRP） with type 2 diabetic nephropathy. Methods According to the urine albumin excretion rate（UAER）,91 patients with type 2 diabetic mellitus were divided into normal-albuminuria group（N-A group： UAER20 μg/min）,micro-albuminuria group（M-A group： UAER 20-200 μg/min） and bulk-proteinuria group（B-P group： UAER200 μg/min）,and 15 healthy subjects served as controls.The serum level of 8-iso-PGF2α was measured using enzyme-linked immunosorbent assay（ELISA） and that of hs-CRP by radioimmunoassay. Results Serum levels of 8-iso-PGF2α and hs-CRP in the three diabetes groups were all significantly higher than that in the healthy controls（F=59.82,57.49;q=8.16-17.92;P0.01）,and that of the diabetes groups were gradually elevated,showing statistically different among the three groups（q=8.57-15.47,P0.01）.Conclusion The changes of serum levels of 8-iso-PGF2α and hs-CRP are closely related to the development of type 2 diabetic nephropathy.

关 键 词：糖尿病 2型 糖尿病肾病 异前列腺素 C反应蛋白质 

分 类 号：R587.1[医药卫生—内分泌]