慢性肾脏病与胰岛素抵抗的关系  

CORRELATION BETWEEN CHRONIC KIDNEY DISEASE AND INSULIN RESISTANCE

作　　者：王虹[1] 王君[1] 唐艳辉[1] 

机构地区：[1]青岛市第八人民医院肾内科,山东青岛266100

出　　处：《齐鲁医学杂志》2011年第2期163-164,共2页Medical Journal of Qilu

摘　　要：目的探讨慢性肾脏病(CKD)与胰岛素抵抗的关系。方法选取2006年7月—2008年12月在我科住院治疗的CKD 3～4期病人56例,以同期35例健康体检者作为正常对照组。测量两组身高、体质量、腰围、血浆葡萄糖、胰岛素、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、超敏C反应蛋白和白细胞介素6,计算稳态模型胰岛素抵抗指数(HOMA-IR)。结果 CKD组与正常对照组之间空腹胰岛素、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、超敏C反应蛋白、白细胞介素6水平和HOMA-IR、腰围、体质量指数差异均有显著性(t=1.755～18.045,P<0.05、0.01)。结论 CKD病人存在着胰岛素抵抗,HOMA-IR可作为CKD病人发生胰岛素抵抗的预测因子。Objective To explore the correlation between the chronic kidney disease（CKD） and insulin resistance.Methods Fifty-six patients with stage 3-4 CKD treated in our department,during July 2006 to December 2008,were enrolled in this study,and 35 healthy persons served as controls The height,weight,waist circumference,plasma glucose,insulin,triacylglyceride,total cholesterol,high density lipoprotein cholesterol,high-sensitivity C-reactive protein and interleukin-6 were measured in both groups,homeostasis model assessment of insulin resistance（HOMA-IR） was calculated. Results The differencesamong the above items measured between the two groups and HOMA-IR were statistically significant（t=1.755-18.045;P0.05,0.01）. Conclusion Insulin resistance exists in CKD patients.HOMA-IR may be used as a parameter to predict insulin resistance in patients with this condition.

关 键 词：肾疾病 胰岛素抗药性 血脂异常 

分 类 号：R692[医药卫生—泌尿科学]