血清C反应蛋白和肌钙蛋白Ⅰ测定在冠心病诊断中的临床应用  

Clinical Value of Serum C-reactive Protein and C-troponin Ⅰ in the Diagnosis of Coronary Heart Disease

作　　者：刘红杏[1] 庞伟鸿[1] 谢虹桥[1] 

机构地区：[1]广东省湛江中心人民医院临床检验中心,广东湛江524037

出　　处：《河北医学》2011年第4期437-439,共3页Hebei Medicine

摘　　要：目的:探讨血清C反应蛋白(CRP)和肌钙蛋白Ⅰ(cTnⅠ)测定在冠心病(CHD)诊断中的应用价值。方法:CRP采用速率散射比浊法测定,cTnⅠ采用化学发光法测定,共检测135例不同类型的CHD患者血清的CRP和cTnⅠ水平。结果:CHD组的CRP和cTnⅠ水平均明显高于正常对照组(P<0.01);不同类型的CHD患者CRP和cTnⅠ浓度比较,急性心肌梗死(AMI)组>不稳定型心绞痛(UAP)组>稳定型心绞痛(SAP)组,差异均有显著性意义(P<0.01)。结论:急性时相蛋白CRP和心肌损伤特异性指标cTnⅠ联合检测,在诊断CHD中可起互补作用,对早期特异性诊断CHD以及病情预后具有重要的意义。Objective： To investigate the clinical value of serum C-reactive protein and C-troponin I for the diagnosis of coronary heart disease. Method： C-reactive protein （CRP）was detected with refraction test and C-troponin I （cTnI） was detected with chemical cllumination test. Both CRP and cTnI levels in 135 cases with different types of coronary heart diseases （CHD） were detected. Result： Both CRP and cTnI levels were higher in study group than those in control group （ P〈0. 01 ）. CRP and cTnI levels were the highest in acute myocardial infarction （AMI） group and the second highest in unstable angina pectoris {UAP） group. Both levels were the lowest in stable angina pectoris （ SAP ） group. The data had statistic significance （ P〈0.01 ）. Conclusion： C-reactive protein combined with cTnI was supplementary for the early specific di- agnosis and the late prognosis of CHD.

关 键 词：冠心病 C反应蛋白 肌钙蛋白I 

分 类 号：R541.4[医药卫生—心血管疾病]