动脉粥样硬化易损斑块的核医学和磁共振分子影像学研究进展  

The Progress of Nuclear Medicine and Magnetic Resonance Molecular Imaging of Atherosclerotic Vulnerable Plaques

作　　者：赵振美[1] 秦树存[1] 

机构地区：[1]泰山医学院动脉粥样硬化研究所,泰安271000

出　　处：《生理科学进展》2011年第2期86-90,共5页Progress in Physiological Sciences

摘　　要：动脉粥样硬化分子影像学通过使用具有敏感性和特异性影像对比的分子探针针对动脉粥样硬化斑块相关的特定分子进行分子成像。该方法会极大地提高对动脉粥样硬化病变特性的检测水平和增强对该病变特征,尤其对斑块的组成成份的识别能力。斑块的组成成份和斑块的破裂、斑块的易损性以及斑块破裂后导致的结果密切相关。因此了解斑块组成成份的在体无创性检测将对动脉粥样硬化病人的治疗和判断预后产生非常重要的临床应用价值。The major goal of atherosclerotic molecular imaging is to target specific plaque-associated molecules with molecular probe that provide sensitive and specific imaging contrast and acquire molecular imaging.This method will greatly improve detection and characterization of atherosclerotic lesions,especially plaque components.The plaque components are highly associated with plaque rupture and vulnerability to rupture as well as the consequences followed plaque rupture.Thus,the knowledge about plaque composition will have tremendous clinical utility in terms of the treatment and prognosis judgment of patients with atherosclerosis.

关 键 词：动脉粥样硬化 易损斑块 分子影像学 核医学成像 磁共振成像 

分 类 号：R331[医药卫生—人体生理学]