Fas/FasL介导的胰岛β细胞凋亡的研究进展  

The Research on Fas/FasL Mediated Pancreatic β Cells Apoptosis

作　　者：李岚[1] 王东[2] 

机构地区：[1]辽宁中医药大学,沈阳110034 [2]辽宁中医药大学附属医院内分泌科,沈阳110032

出　　处：《医学综述》2011年第8期1124-1126,共3页Medical Recapitulate

基　　金：辽宁省科技厅博士启动基金项目(20041038);辽宁省教育厅青年基金项目(20040214)

摘　　要：细胞凋亡是细胞在生理和病理情况下的一种死亡模式,凋亡过程受基因严格控制。胰岛β细胞凋亡对各种促凋亡刺激非常敏感,在糖尿病的的发病中扮演了重要角色。Fas和FasL为近年来研究较多的凋亡调控基因,在胰岛β细胞凋亡中起着重要的调节作用。现主要通过探讨糖尿病胰岛β细胞凋亡与Fas/FasL的关系,以深入认识糖尿病的发病机制,更好地防治糖尿病。Apoptosis is a death mode of cells under physiological and pathological conditions,whose process is controlled by genes.The apoptosis of pancreatic β cells is sensitive to all sorts of promoting apoptosis stimulation,and plays an important role in the incidence of diabetes.Fas and FasL are two of more apoptosis genes which are researched in recent years,and plays an important regulatory role in the apoptosis of pancreatic β cells.This paper is for deeply understanding of the pathogenesis of the diabetes and betterly controling diabetes mainly through investigating the relationship between the pancreatic β apoptosis in diabetes and Fas/FasL.

关 键 词：糖尿病 FAS/FASL 胰岛Β细胞 凋亡 

分 类 号：R587.1[医药卫生—内分泌]