肾素抑制剂阿利吉仑在心血管疾病中应用的研究进展  

Research Advances of Aliskiren for the Treatment of Cardiovascular Diseases

作　　者：华锦胜 马礼坤 

机构地区：[1]安徽医科大学附属省立医院心内科,合肥230022

出　　处：《医学综述》2011年第8期1214-1216,共3页Medical Recapitulate

摘　　要：肾素-血管紧张素-醛固酮系统的激活在心血管疾病发生、发展中起着重要的作用。作为肾素-血管紧张素-醛固酮系统上游激素-肾素的抑制剂,阿利吉仑被证实不仅具有良好的降压作用,而且具有独立于降压之外的心血管保护作用。现就近年来阿利吉仑在心血管疾病中的应用研究进展予以综述。This increased activity of renin-angiotensin-aldosterone system plays a key role in the occurrence of cardiovascular diseases.ACEI,ARB,and aldosterone antagonists are effective in the protection and treatment of some cardiovascular diseases.Aliskiren,a renin inhibitor,blocks the activation of renin-angiotensin system.Previous studies have shown that aliskiren can be antihypertensive and be beneficial for cardiovascular disease independent of lowering blood pressure.This article reviews the research advances in the use of aliskiren for the treatment of cardiovascular diseases.

关 键 词：阿利吉仑 肾素-血管紧张素-醛固酮系统 高血压 心血管疾病 

分 类 号：R972.14[医药卫生—药品]