母爱剥夺损害大鼠的情绪记忆  

Early maternal deprivation impairs emotional memory in rats

作　　者：金晶[1] 张旭亮[1] 杨李果[1] 徐浩[1] 曾庆文[1] 曹晓华[1] 

机构地区：[1]华东师范大学脑功能基因组学教育部及上海市重点实验室,上海200062

出　　处：《华东师范大学学报（自然科学版）》2011年第2期163-170,共8页Journal of East China Normal University(Natural Science)

基　　金：上海市脑功能基因组学重点实验室自主项目(44501645)

摘　　要：为了探究母爱剥夺对大鼠认知和记忆能力的影响,将新生SD大鼠分为对照组和母爱剥夺组,成年后进行记忆能力测试.结果表明,母爱剥夺组大鼠在开场实验中的活动量和探索行为正常;新异物体识别实验中,母爱剥夺组鼠在新物体上探究的时间也与对照组相当;而在明暗箱被动回避实验中,母爱剥夺组大鼠的逃避潜伏期显著短于对照组,表现出恐惧记忆能力明显减弱.由于被动回避的恐惧记忆和新异物体识别依赖于不同的脑区,以上的数据表明,母爱剥夺可能损害了大鼠杏仁核脑区相关的情绪记忆.The experiment was designed to investigate the effect of early maternal deprivation on cognition and memory in rats.The neonatal SD rats were divided into two groups randomly,the control group and the early maternal deprivation group.All rats were tested in the different behavioral paradigms in adult period.No significant difference was measured in locomotor activity and exploration between two groups in the open field test.In the novel object recognition test, there was also no significant difference in exploratory preference to the novel object.However, compared with the controls,rats in the early maternal deprivation group exhibited short escape latency in the passive avoidance test,suggesting early maternal deprivation impairs fear memory of rats.These results indicate that early maternal deprivation may impair amygdala-dependent emotional memory in rats.

关 键 词：母爱剥夺 被动回避 新异物体识别 

分 类 号：Q427[生物学—神经生物学]