基质金属蛋白酶及其抑制物在正常和异位子宫内膜中的表达  

The expression of matrix metalloproteinase and its inhibitor in eutopic and ectopic endometria

作　　者：王丽[1] 李东爽 郭雪霏 

机构地区：[1]解放军305医院,北京100017

出　　处：《浙江临床医学》2011年第4期364-365,共2页Zhejiang Clinical Medical Journal

摘　　要：目的研究基质金属蛋白酶2、9（Matrix metalloprotein MMP2、MMP9）和基质金属蛋白酶抑制剂1（TIMP1）与子宫内膜异位症的相关性.方法采用免疫组化方法检测MMP2、MMP9、TIMP1蛋白的表达.结果 异位子宫内膜标本中MMP2表达增强,MMP9、TIMP1的表达在各组之间差异无统计学意义.结论 MMP2可能与子宫内膜异位症的发生密切相关.Objective To evahtate the expression and localization of matrix metalloproteinase2,9 （MMP2, MMP9）and tissue inhibitor of matrix metollaproteinase 1 （ TIMP1 ） in endometriosis. Method The expression of MMP2, MMP9 protein on paraffin - embeded tissues was determined by immunohistochemical analysis. Results Endometriotic tissues showed statisticaly stronger MMP2 protein compared with eutopie endometfia （P 〈0.05 ）. MMP9 ,TIMP1 expresion were same in eutopic endometria and ectopic endometria. Conclusion Compared to eutopie endometrium, ectopic endometrium has a higher capacity to produce MMP2.

关 键 词：子宫内膜异位症 基质金属蛋白酶2、9 基质金属蛋白酶抑制剂 

分 类 号：R587.2[医药卫生—内分泌]