内脂素与冠心病关系的探讨  

Study on the relationship between serum level of visfatin and coronary heart disease

作　　者：周桂建[1] 张宁汝[1] 张恒[1] 田涛[1] 陈斌[1] 汤阳[1] 戎成振[1] 

机构地区：[1]蚌埠医学院第一附属医院心内科,233004

出　　处：《中国综合临床》2011年第4期384-386,共3页Clinical Medicine of China

摘　　要：目的 探讨血清内脂素水平与冠心病的关系.方法 88例住院患者,根据冠状动脉造影的结果分为冠心病组（62例）及对照组（26例）,其中冠心病组分为单支病变组、双支病变组、多支病变组,采用ELISA法测定内脂素.同时记录冠心病患者Gensini冠脉病变积分,并与血清内脂素进行相关性分析.结果 冠心病组患者血清内脂素明显高于对照组[（10.77±2.63）μg/L与（7.13±2.06）μg/L,t=-6.283,P＜0.01].内脂素随冠状动脉病变支数的增加而升高（P＜0.05）.冠状动脉造影正常、单支病变、双支病变、多支病变的患者,其血清中内脂素水平分别为（7.13±2.06）、（9.30±2.19）、（10.81±2.12）、（12.79±2.20）μg/L.血清内脂素与Gensini冠脉病变积分呈显著正相关（r=0.483,P＜0.01）.结论 内脂素升高与冠心病密切相关,内脂素浓度越高,冠状动脉病变越严重.Objective To study the relationship of serum visfatin level and coronary heart disease （CHD）. Methods Eighty eight hospitalized patients were enrolled into the study and divided into CHD group（n = 62） and non-CHD control group（n = 26） according to the angiography results; the CHD group was further divided into single-, double-, multi-vessel affected groups. The serum level of visfatin was measured by ELISA,the lesion severity of coronary arteries was assessed by Gensini coronary scoring system, and the correlation between serum visfatin level and coronary lesion severity was evaluated statistically. Results The level of serum visfatin was significantly higher in CHD group than the control group（[ 10. 77 ± 2. 63 ] μg/L vs. [ 7. 13 ± 2. 06 ]μg/L,P 〈 0. 05）. The visfatin level increased along with the the number of stenosis vessels（P 〈 0. 05）. The sermn visfatin levels of no stenosis, single-, double-, multi-vessel groups were（7. 13 ± 2. 06） μg/L,（9. 30±2. 19） μg/L,（10. 81 ± 2. 12） μg/L,（12. 79 ± 2. 20） μg/L respectively. A significant positive correlation was found between coronary lesion severity score and serum visfatin level（r = 0. 483, P 〈 0. 01）. Conclusion The visfatin may be directly related to the initiation and development of coronary diseases. The higher level of serum visfatin was, the more severe coronary artery disease would be.

关 键 词：冠心病 内脂素 GENSINI积分 

分 类 号：R541.4[医药卫生—心血管疾病]