基于动物热活性检测系统分析动物热活性影响因素  

Study on Influencing Factor of Animal Thermal Activity Based on the Animal Thermal Activity Determination System

作　　者：赵海平[1,2] 赵艳玲[1] 王伽伯[1] 鄢丹[1] 金城[1] 张萍[1] 王永炎[3] 肖小河[1] 

机构地区：[1]中国人民解放军第三〇二医院全军中药研究所,北京市100039 [2]江西中医学院 [3]中国中医科学院

出　　处：《中医杂志》2011年第9期770-772,775,共4页Journal of Traditional Chinese Medicine

基　　金：国家高技术研究发展计划(“863”计划)资助项目(2007CB512607,2006CB504703);国家杰出青年科学基金(30625042)

摘　　要：目的基于动物热活性监测系统进行动物热活性影响因素分析,以期对中药寒热药性评价进行方法学探索。方法采用动物热活性监测系统,考察品种、性别及适应时间对ICR、BALB/c及KM种小鼠在不同温区停留时间比例（RTR）的影响。结果 ICR、BALB/c种小鼠可耐受最低温度为15℃,最高为40℃;与适应前比较,15℃温区内ICR、BALB/c、KM种小鼠分别在6、8、4h,30℃温区内分别在6、6、4h,40℃温区内分别在4、6、8h,RTR值均开始减少（P〈0.05）;雌、雄性KM小鼠在15~40℃温区的RTR值差异无统计学意义（P〉0.05）。结论在动物热活性监测系统中,3个品种小鼠的可耐受温度范围大致为15~40℃,累计适应4~8h后对温区间温差能形成相对稳定的记忆,且雌、雄性KM小鼠对同一温度的感知基本一致。Objective To study the influencing factor of animal thermal activity based on the animal thermal activity determination system,to explore the methodology of evaluation of cold/hot nature of Chinese medicine.Methods By using the cold/hot plate differentiating instrument,the influence of different breeds,sex and adaptation time on the remaining time ratio（RTR） of ICR,BALB/c and KM mice at different temperature areas was studied.Results The tolerable temperature of ICR,BALB/c mice was between 15℃ and 40℃.Compared with before adaptation,the RTR of ICR,BALB/c and KM mice began to be depressed（P0.05） in 6,8,and 4h in 15℃ temperature area,in 6,6,and 4h in 30℃ temperature area,and in 4,6,and 8h in 40℃ temperature area.The RTR of female and male KM mice in 15℃ to 40℃ temperature area were not significantly different（P0.05）.Conclusion In this detective system,the tolerable temperature of ICR,BALB/c,and KM healthy mice would be 15～40℃,a relative stable memory could be obtained after 4～8h adaptation,and the perception of male and female KM mice to the same temperature might be almost the same.

关 键 词：动物热活性监测系统 品种 适应时间 性别 停留时间比例 

分 类 号：R285.1[医药卫生—中药学]