哒嗪和哒嗪酮碳核苷类似物的合成  

SYNTHESIS OF PYRIDAZINE AND PYRIDAZINONECNUCLEOSIDE ANALOGUES

作　　者：孙德群[1,2] 朱京[1,2] 马灵台 张礼和 

机构地区：[1]中国科学院成都有机所 [2]北京医科大学药学院

出　　处：《华西药学杂志》1999年第3期149-151,共3页West China Journal of Pharmaceutical Sciences

摘　　要：用杂环金属盐法，通过呋喃碳核苷中间体，合成了哒嗪、哒嗪酮等碳核苷，并讨论了反应机理提高了呋喃汞盐合成碳核苷的收率及立体选择性。New Cnucleoside analogues were synthesized via the key intermediate 2(2',3',4'triObenzoylDxylopyranosyl)furan.The stability of the and isomer was described. The conversion of the furan ring into pyridazine ring was performed by ClassonKaas method to give 3(Dxylopyranosyl)pyridazine and 3(Dxylopyranosyl4,5dihydro6(1H))pyridazinone.

关 键 词：哒嗪 哒嗪酮 碳核苷 类似物 合成 

分 类 号：TQ463.24[化学工程—制药化工]