载药羟基磷灰石人工骨修复骨缺损的实验研究  

EXPERIMENTAL STUDY ON REPAIRING BONEDEFECT BY CPHA

作　　者：孙伟[1] 张景利 曾仁杰[1] 张勤[1] 郑慰[1] 王雪[1] 

机构地区：[1]成都军区总医院药学部

出　　处：《华西药学杂志》1999年第3期172-174,共3页West China Journal of Pharmaceutical Sciences

摘　　要：用载药羟基磷灰石陶瓷人工骨（Ｃ－ＰＨＡ）进行家兔骨缺损修复。实验表明，蜂蜡包裹的Ｃ－ＰＨＡ在家兔体内具有明显的药物缓释作用，２７周局部组织仍含有效药物浓度。新生骨可顺利长入Ｃ－ＰＨＡ材料，术后１８周，材料表面全部被板层骨覆盖。蜂蜡不影响植入区的新骨长入和骨缺损的修复，亦不影响ＰＨＡ发生生物降解。Repairing the bone defect of rabbits by CPHA was studied. It was demonstrated that the CPHAwax in vivo of rabbits had obvious sustained release behaviour, the drug can still be detected in the location tissue after 27 weeks. The new bone cells could grow favorably in CPHA. The new bone growth, repairing of bone defect and PHA biodegradation were not effected by wax.

关 键 词：C-PHA 人工骨 头孢氨苯 骨缺损 修复 实验研究 

分 类 号：R687.3[医药卫生—骨科学] R318.08[医药卫生—外科学]