罗布麻叶浸膏对脑内单胺类递质含量及细胞膜流动性的影响  

Effects of Indian Hemp (Apocynum venetum) Leaf Extract on Monoamine Transmitter and Cell Membrane Fluidity in Brain

作　　者：潘建新[1] 顾振纶[1] 钱曾年[1] 秦正红 许美凤[1] 石琳[1] 

机构地区：[1]苏州医学院药理学教研室,215007

出　　处：《中草药》1999年第7期517-520,共4页Chinese Traditional and Herbal Drugs

基　　金：江苏省医药总公司资助项目

摘　　要：罗布麻叶浸膏可使脑内５－ＨＴ及ＤＡ含量升高，其水溶性成分可使５－ＨＴ、５－ＨＩＡＡ及ＤＡ 含量升高，而ＮＥ含量降低，醇溶性成分上述作用更为明显。提示罗布麻叶浸膏可能含有兴奋中枢 ５－ＨＴ神经元功能及抑制中枢肾上腺素神经元功能的化学物质，这些化学物质为水溶性及酸溶性。 脑神经细胞膜脂质流动性测定结果提示罗布麻叶浸膏水溶性部分可使膜流动性增加。Extract of Apocynum venetum leaves can markedly increase levels of 5-HT and DA in the brain. Its water-soluble portion elevated the levels of 5-HT, 5-HIAA and DA but lowered that of NE. The effects of its alcoholic soluble portion were even more evident. These results suggested that extract of A. venetum leaves might contain chemical substances which can excite serotonergic neuron but inhibit adrenergic neuron of central nervous system. These substances are either water soluble or alcoholic soluble. Results obtained by determing the lipid fluidity of cell membrane showed that the water soluble component of A. venetum leaves improved the cell membrane fluidity in brain.

关 键 词：罗布麻叶浸膏 单胺类递质 脑神经 细胞膜流动性 

分 类 号：R285.5[医药卫生—中药学]