锰对大鼠子代脑锥体外系发育的影响  

Effect of manganese on the brain extrapyramidal development of rat offspring

作　　者：张德兴[1,2,3] 贺新红[1,2,3] 张文光 檀进发[1,2,3] 黄绍明 

机构地区：[1]广东药学院基础学科部 [2]广西医科大学解剖学教研室 [3]加拿大卡尔顿大学生命科学研究中心

出　　处：《卫生研究》1999年第4期214-217,共4页Journal of Hygiene Research

基　　金：国家自然科学基金

摘　　要：母鼠及子鼠饮用含氯化锰（２ｇ／Ｌ或１０ｇ／Ｌ）的水，研究锰对大鼠子代行为和脑锥体外系发育的影响。结果显示：（１）在“ＥｌｅｖａｔｅｄＰｌｕｓＡｒｍｓＭａｚｅ”迷宫测试中，染锰组仔鼠从中央区进入第一臂的潜伏期缩短，但进入开放臂的次数与对照组无差异；在Ｍｏｒｒｉｓ水迷宫肌力测试中，各组动物仔鼠到达平台的时间无差异。（２）高剂量染锰组尾状核和伏隔核的面积、胶质细胞纤维酸蛋白免疫反应强度及反应阳性产物的平均相对密度均较对照组显著升高；（３）高剂量组仔鼠黑质、中脑腹侧被盖区和尾状核的酷氨酸氢氧化酶免疫反应强度及其反应阳性产物的平均相对密度均比对照组明显下降。The effect of manganese (Mn)exposure on the behavior and extrapyramidal system of offspring were studied.Pregnant rats and their offspring in the experimental group were exposed to manganese from drinking water containing 2g/L (low Mn exposed group) or 10g/L (high Mn exposed group)of MnCl 2 respectively. The latent period for running from the center field to any arm of Elevated Plus Arm Maze of both low and high Mn exposed group was significantly reduced. But the latent period for reaching the platform above the water in Morris Water Maze of the Mn exposed group was not different from that of control group. There was a significant increase in the areas,glial fibrillary acid protein(GFAP)immunoreactivity and the average proportional densities of GFAP positive elements in nucleus caudate and accumbens in the high Mn exposed group, and a significant reduction in the tyrosine hydroxylase immunoreactivity (TH) and average proportional densities of TH positive elements in substantia nigra,ventral tegmentum area of midbrain and nucleus caudate in the high Mn exposed group.

关 键 词：锰中毒 大鼠 脑发育 锥体外系 发育毒性 

分 类 号：R992[医药卫生—毒理学] R715[医药卫生—药学]