小剂量17β-雌二醇对预防卵巢切除大鼠骨丢失的研究  

Effect of physiological dosage of estrogen on the prevention of bone loss in rats induced by ovariectomy

作　　者：高秀辉[1,2,3] 薛延[1,2,3] 颜卉君[1,2,3] 郑铭豪[1,2,3] 

机构地区：[1]北京市创伤骨科研究所骨与关节病研究中心 [2]北京师范大学生物系 [3]澳大利亚西澳大学外科系

出　　处：《卫生研究》1999年第4期227-229,共3页Journal of Hygiene Research

摘　　要：为观察生理剂量的１７β－雌二醇（Ｅ２）对卵巢切除大鼠骨代谢、骨密度和骨力学特性的影响。将大鼠分为假手术组（Ａ）、去卵巢组（Ｂ）和去卵巢并给雌二醇组（Ｃ）。给Ｅ２９周后同时处死各组大鼠。结果Ｂ组大鼠血清碱性磷酸酶（ＡＬＰ）和骨钙素（ＯＣ）水平明显上升，右股骨近端１／３及第三腰椎骨密度（ＢＭＤ）明显低于对照组，雌二醇可逆转上述情况。Ｂ组骨力学参数明显低于对照组，而Ｃ组力学参数未见好转。结论认为生理剂量Ｅ２可抑制骨吸收和骨形成并增强骨量，但骨强度未见明显改善。The effect of small dosage of 17β estradiol(E 2) on bone metabolism,bone mineral density (BMD) and biomechanical properties of bone in ovariectomized rats were observed.Twenty one rats were divided into three groups.They were sham operated group (A),ovariectomized group(B),and ovariectomized and treated with 17β estradiol group (C).Rats were sacrificed after 9 weeks of treatment.Serum alkaline phosphatase(ALP) and osteocalcin(OC) contents were significantly increased;bone mineral content(BMC) of right femur and the third lumbar body(L 3) and the biomechanical properties of right femur were decreased in group B.Treatment with E 2 can reverse the changes of BMD and BMC in ovariectomized rats.There was no significant improvement on biomechanical parameters in group C rats.It is concluded that physiological dosage of E 2 may inhibit bone resorption and bone formation and increase bone mass,but it may not improve the strength of bone.

关 键 词：卵巢切除 雌二醇 骨质疏松 预防 

分 类 号：R977.1[医药卫生—药品] R681[医药卫生—药学]