1-(4-氯苯基)-3-吡唑醇的合成  

Synthesis of 1-(4-Chlorophenyl)-3-hydroxypyrazole

作　　者：丁成荣[1] 范杰[1] 夏光华[1] 项继聪[1] 何胜利[1] 张国富[1] 

机构地区：[1]浙江工业大学化学工程与材料学院,杭州310032

出　　处：《农药》2011年第5期327-328,349,共3页Agrochemicals

基　　金：国家自然科学基金(20702051);浙江省教育厅科研计划项目(Y200907685);浙江省化学工程与新材料研究生教育创新示范基地(2009)

摘　　要：[方法]1-(4-氯苯基)-3-吡唑醇是一种重要农药中间体,以对氯苯肼为原料经环合、氧化,合成1-(4-氯苯基)-3-吡唑醇。[结果]在优化的反应条件下,1-(4-氯苯基)-3-吡唑醇的反应总收率为72.5%(以对氯苯肼计),含量为99.2%,其结构经红外和氢谱核磁分析确证。[结论]该工艺具有反应条件温和、产品收率高等优点,适合工业化生产。[Methods]As an important intermediate of pesticides,1-（4-chlorophenyl）pyrazolidin-3-one could besynthesized by the cyclization and oxidation from the raw material 4-chlorophenylhydrazine.[Results]Under the optimalcondition,the total yield was 72.5%based on 4-chlorophenylhydrazine and the purity was 99.2%.The structure of theresulting product was confirmed by IR and1H NMR.[Conclusions]The process exhibited mild reaction conditions andhigh yield,and is suitable for industrial production.

关 键 词：对氯苯肼 1-(4-氯苯基)-3-吡唑醇 合成 

分 类 号：TQ450.2[化学工程—农药化工]