农用杀菌剂腈菌唑光学对映体的生物活性  

Bioactivity Investigation of Fungicide Myclobutanil Enantiomers

作　　者：邓朱波[1] 胡继业[1] 

机构地区：[1]北京科技大学化学与生物工程学院,北京100083

出　　处：《农药》2011年第5期371-373,共3页Agrochemicals

摘　　要：[目的]采用高效液相色谱法拆分制备了腈菌唑光学对映体。采用菌丝生长速率法测定了腈菌唑外消旋体及其对映体对苹果轮纹病菌、小麦赤霉病菌、梨黑斑病菌和番茄早疫病菌的生物活性,比较了对映体间杀菌活性的差异。[结果]对苹果轮纹病菌,(+)-腈菌唑和(-)-腈菌唑的EC50值分别为2.644 1、8.692 7 mg/L;对小麦赤霉病菌,二者的EC50值分别为0.738 1、4.415 7 mg/L;对于梨黑斑病菌,二者的EC50值分别为8.789 9、20.774 4 mg/L;对番茄早疫病菌,二者的EC50值分别为5.312 0、12.836 5 mg/L。[结论]对于供试菌种而言,(+)-腈菌唑杀菌活性显著优于(-)-腈菌唑。Myclobutanil racemate was separated using HPLC and its pure enantiomers were prepared.Bioactivity of the racemate and pure enantiomers on Physalospora piricola,Gibberella zeae,Alternaria kukuchianaand Alternaria solani was tested by growth rate method to compare the difference of fungicidal activity betweenenantiomers.[Results]For P.piricola,EC50of（＋）-enantiomer and（-）-enantiomer is 2.6441,8.6927 mg/L,respectively.For G.zeae,EC50is 0.7381,4.4157 mg/L,respectively.For A.kukuchiana,EC50is 8.7899,20.7744 mg/L,respectively.For A.solani,EC50is 5.3120,12.8365 mg/L,respectively.[Conclusions]Antifungicidal activity of（＋）-myclobutanil is obviously superior to（-）-myclobutanil.

关 键 词：腈菌唑 对映体 杀菌活性 

分 类 号：S482.2[农业科学—农药学]