坎地沙坦和氨氯地平对原发性高血压早期肾损害的影响  

Effect of candesartan and amlodipine on primary hypertension with early renal damage

作　　者：程水进[1] 吴继雄[1] 陈万林[2] 

机构地区：[1]安徽医科大学第二附属医院心内科,安徽合肥230601 [2]安徽医科大学第二附属医院检验科,安徽合肥230601

出　　处：《安徽医药》2011年第4期495-497,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的旨在探讨坎地沙坦和氨氯地平对原发性高血压早期肾损害的疗效。方法对83例门诊原发性高血压(1级、2级)伴尿微量白蛋白阳性的患者按就诊顺序用数字随机法分为氨氯地平组(5 mg·d-1)42例和坎地沙坦组(8 mg·d-1)41例,疗程3个月。观察治疗前后血压、血肌酐(Scr)、尿微量白蛋白(UMALB)、尿α1微球蛋白(Uα1-MG)、血清胱蛋白酶抑制剂C(CystC)的变化。结果两组血压均较治疗前明显降低(P<0.01),但两组治疗后血压比较,差异无统计学意义(P>0.05);两组治疗前后Scr无统计学意义(P>0.05);两组UMALB、CystC均较治疗前降低(P<0.05),两组治疗后比较坎地沙坦组优于氨氯地平组(P<0.05);两组Uα1-MG均较治疗前明显降低(P<0.01),两组治疗后比较坎地沙坦组明显优于氨氯地平组(P<0.01)。结论坎地沙坦和氨氯地平都有良好的降压作用,并且都能降低UMALB、Uα1-MG、CystC的水平,但坎地沙坦对原发性高血压早期肾损害的保护作用优于氨氯地平。Aim To investigate the efficacy of candesartan and amlodipine on primary hypertension with early renal damage.Methods 83 microalbuminuria positive outpatients with essential hypertension（1,2）were divided into amlodipine group（5 mg·d-1）with 42 cases and candesartan group（8 mg·d-1）with 41 cases according to the order of visits,with a course of 3 months.The difference was observed in blood pressure,Scr,UMALB,Uα1-MG and CystC before and after treatment.Results Blood pressure of the two groups descended more significantly than those before treatment（P0.01）,but comparing the blood pressure between the two groups after treatment,the difference is not significant（P0.05）;Scr of the two groups had no changes before and after treatment（P0.05）;UMALB and CystC of the two groups are lower than those before treatment（P0.05）,and the candesartan group was better than amlodipine group（P0.05）.So are Uα1-MG of the two groups,with a significant drop（P0.01）.Conclusion Both candesartan and amlodipine have a good antihypertensive effect to reduce levels of UMALB,Uα1-MG and CystC,but the effect of candesartan is better than that of amlodipine on primary hypertension with early renal damage.

关 键 词：坎地沙坦 氨氯地平 尿微量白蛋白 尿Α1微球蛋白 血清胱蛋白酶抑制剂C 

分 类 号：R544.1[医药卫生—心血管疾病]