绝经后女性骨密度与中心脉压关系的探讨  

Study on the Relationship between Bone Mineral Density and Central Pulse Pressure in Postmenopausal Women

作　　者：陈鹏[1] 李继武[1] 张素勤[1] 

机构地区：[1]温州医学院附属第二医院心内科,浙江温州325000

出　　处：《心脑血管病防治》2011年第2期87-89,I0001,共4页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

摘　　要：骨质疏松症是一种全身性的骨骼疾病,随着年龄的增大而日渐严重,特别在绝经后女性人群中,这种骨代谢异常表现得尤为显著。近年来,人们注意到伴随着钙代谢异常的骨质疏松症常伴有动脉血管钙化和硬化[1,2],提示两者之间可能存在着共同的发病机制。本文通过对155例绝经后女性骨密度和有创中心动脉压测定,旨在探讨绝经后女性人群骨密度降低与动脉硬化之间的关系,为这两种绝经后女性人群常见疾病的综合防治寻找科学的理论依据。Objective To observe the relationship between bone mineral density（BMD） and central pulse pressure（CPP）in postmenopausal women.Methods One hundred and fifty five postmenopausal women aged 46-83 years old were included in this study.The levels of BMD in the lumbar spine（L1-L4） and the right femoral neck were determined in all patients with dual-energy x-ray absorptiometry（GE Lunar Co）.Their brachial blood pressure was measured by mercury sphygmomanometer and the central arterial blood pressure was measured by 5F JR catheter.The levels of serum lipid（total cholesterol,triglyceride cholesterol,high-density-lipoprotein-cholesterol,low-density-lipoprotein-cholesterol）,serum creatinine and fasting-plasma-sugar（FBG） were measured with Japanese automatic biochemistry analyzer.All data were analysed with SPSS software and multiple stepwise regression analysis.Results 1.Pearson＇s correlation analysis showed that CPP was significantly related to age,FBG,heart rate,BMD in femoral neck and serum creatinine.2.The multiple factors stepwise regression analysis showed that the regression of CPP only with age,heart rate and BMD in the femoral neck was of great significance.Conclusions This study indicated that loss of bone mineral density in the femoral neck was an independent risk factor for CPP increase in postmenopausal women.

关 键 词：绝经后女性 骨密度降低 中心脉压 骨质疏松症 中心动脉压 女性人群 动脉硬化 骨代谢异常 

分 类 号：R580[医药卫生—内分泌]