慢性乙型病毒性肝炎病毒复制与肝癌的相关性研究  

Clinical Study on the Relationship between Viral Replication of Chronic Hepatitis B and Occurrence of Liver Cancer

作　　者：梁丽 范恒[1] 唐庆[1] 胡建莉[2] 廖奕[1] 陈小艳[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院中西医结合科,武汉430022 [2]华中科技大学同济医学院附属协和医院肿瘤中心,武汉430022

出　　处：《中西医结合研究》2011年第2期57-61,共5页Research of Integrated Traditional Chinese and Western Medicine

基　　金：国家自然科学基金课题(No.30772878)

摘　　要：目的探讨慢性乙型病毒性肝炎(简称乙肝)与肝癌的相关性及其癌变机制,从而预防乙肝的发生、发展,减少肝癌的发生。方法研究武汉市协和医院2008年10月—2009年2月所有肝癌患者的临床资料,并分析目前肝癌的发病原因及其与乙肝的相关性。结果本院5个月共收治313例肝癌,其中罹患有乙肝的患者212例,无乙肝病史的有83例,有至少67.7%的患者有乙肝病史,有73.2%不经过肝硬化直接发展为肝癌。结论肝癌的发生与乙肝病毒复制有极大的相关性,可以从早期防治乙肝为切入点,定期复查乙肝病毒DNA(HBV DNA),对控制肝癌的发生十分必要,并提出应重视抗病毒治疗的策略。Objective To investigate the relationship and the pathogenesis between chronic hepatitis B and liver cancer,and prevent the occurrence and development of hepatitis B in order to reduce the occurrence of liver cancer.Methods Analyzing the clinical data of patients with hepatocellular carcinoma in Wuhan Union Hospital from October 2008 to February 2009,we investigated the reasons for the current incidence of liver cancer and the relationship of liver cancer with hepatitis B.Results A total of 313 patients with liver cancer were enrolled in 5 months.212 patients suffered from hepatitis B whereas 83 without hepatitis B.There were at least 67.7 % patients with hepatitis B.73.2% patients developed directly into the liver cancer without going through the stage of liver cirrhosis.Conclusion There was the significant relevance between the occurrence of liver cancer and hepatitis B viral replication.The study highlight the early prevention and treatment of hepatitis B viral replication,regular monitoring HBV DNA is important to control the occurrence of liver cancer,and we should pay much attention to the treatment strategies of anti-virus.

关 键 词：肝癌 慢性乙型病毒性肝炎 HBV DNA 抗病毒 

分 类 号：R512.62[医药卫生—内科学]