N^(5,10)-亚甲基四氢叶酸还原酶基因多态性与颅内动脉瘤的关系  

The relationship of polymorphism of methylenetetrahydrofolate reductase gene and Intracranial aneurysm

作　　者：邓维意[1] 孙卫文[1] 戴文伟[1] 许绍强 伍建伟[1] 李明昌[1] 何伟文[1] 陆永健[1] 陈盛强[1] 

机构地区：[1]广州医学院第二附属医院,广东广州510120 [2]广州三九脑科医院,广东广州510120

出　　处：《河南预防医学杂志》2011年第2期89-91,共3页Henan Journal of Preventive Medicine

基　　金：广州市卫生科技项目(A2009270)

摘　　要：目的探讨同型半胱氨酸和N5,10-亚甲基四氢叶酸还原酶(MTHFR)基因多态性与颅内动脉瘤的关系。方法运用多聚酶链反应技术检测76例颅内动脉瘤及77例正常人MTHFR基因多态性。结果颅内动脉瘤组的MTHFR C677T CT基因型频率较正常对照高(P<0.01),患颅内动脉瘤的风险是对照组的2.57倍,两组等位基因频率差异无统计学意义(P>0.05)。结论 MTHFR CT基因型与颅内动脉瘤明显相关。Objective To explore relationship of polymorphism of methylenetetrahydrofolate reductase gene（MTHFR）with Intracranial aneurysm.Method The genotyes of MTHFR were determined by PCR-based assay in 76 patients with Intracranial aneurysm and 77 healthy controls.Results There were siganificant differences in the CT genotype frequenceies of methylenetetrahydrofolate reductase mutations between the patients and central groups（P〈0.01）.Conclusions methylenetetrahydrofolate reductase CT genotype may be independent risk factors for Intracranial aneurysm.

关 键 词：同型半胱氨酸 颅内动脉瘤 N5 10-亚甲基四氢叶酸还原酶 多态性 

分 类 号：R136.2[医药卫生—劳动卫生]