早期血液灌流联合乌司他丁治疗急性有机磷农药中毒的研究  

Research of Early Hemoperfusion plus Ulinastatin Treatment in Patients with Acute Organophosphorus Pesticide Poisoning

作　　者：张文忠[1] 张雪梅[1] 吴楠[1] 王玲[1] 焦清海[1] 赵冉冉[1] 刘冬青[2] 

机构地区：[1]邯郸市第一医院急诊科,邯郸056002 [2]邯郸市第一医院检验科,邯郸056002

出　　处：《四川解剖学杂志》2011年第1期20-22,共3页Sichuan Journal of Anatomy

基　　金：河北省邯郸市科学技术研究与发展计划项目(编号:1020108098)

摘　　要：目的探讨早期血液灌流联合乌司他丁治疗急性有机磷农药中毒(AOPP)的效果。方法选取64例重度AOPP患者随机分为治疗组32例和对照组32例,全部患者均进行常规内科治疗,治疗组在此基础上行早期血液灌流联合乌司他丁应用。观察全部病例的阿托品应用总量,胆碱酯酶活力(CHE)恢复时间、病死率及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)水平的变化。结果治疗组阿托品应用总量、CHE活力恢复时间、病死率均低于对照组(P<0.05或P<0.01)。治疗组IL-6、TNF-α、CRP水平较对照组降低(P<0.05)。结论早期血液灌流联合乌司他丁应用能迅速有效清除毒物和抑制炎症因子,干预炎性反应,保护脏器功能,有效改善重度AOPP患者预后。Objective To investigate the effects of early hemoperfusion plus Ulinastatin treatment in patients with acute organophosphorus pesticide poisoning（AOPP）.Methods Sixty-four patients with severe AOPP were randomly divided into the treatment group of the 32 cases,and the control group of 32 cases.All patients were given conventional medical treatment,the treatment group were additionally given early hemoperfusion plus Ulinastatin treatment.The total atropine dosage of all the patients was observed,and the recovery time of cholinesterase,the level of IL-6,TNF-α and C-reaction protein（CRP） were also detected.Results The atropine dosage,the recovery time of cholinesterase,and the mortality in the treatment of group were lower than that in the control group（P0.05 or P0.01）.The level of IL-6,TNF-α and CRP in the treatment group were lower than that in control group（P0.05）.Conclusion Early hemoperfusion plus Ulinastatin treatment can rapidly and effectively eliminate the organophosphorus insecticides and the inflammatory factors,decrease the injury of the organs,and raise the survival rate of severe AOPP.

关 键 词：早期 血液灌流 乌司他丁 急性有机磷中毒 重度 

分 类 号：R595.4[医药卫生—内科学]