ATP敏感性钾通道开放剂的脑保护作用研究  

Role of ATP-sensitive Potassium Channel Openers in Brain Protection

作　　者：陈晓仰[1] 林霓阳[1] 

机构地区：[1]汕头大学医学院第一附属医院儿科,广东汕头515041

出　　处：《医学综述》2011年第7期979-981,共3页Medical Recapitulate

基　　金：2009年广东省科技计划项目(2009B030801326)

摘　　要：细胞上存在两种三磷酸腺苷敏感性钾(KATP)通道,一是位于细胞膜上的ATP敏感的钾通道;二是位于线粒体膜上的ATP敏感的钾通道。KATP通道广泛存在于各种脑区,若给予KATP开放剂则可以使其开放发挥对脑的保护作用。越来越多的研究表明,KATP通道在脑缺氧缺血等病理状态下被激活开放,使大量K+外流,细胞膜超极化,从而使Na+、Ca2+内流减少,避免或减轻钙超载、减少能耗、减轻兴奋性氨基酸及氧自由基释放,保护脑细胞。Two distinct ATP-sensitive K＋（KATP） channels have been described in cells,namely,cell membrane KATP channel and mitochondrial KATP channel.KATP channel exists widely in brain regions,which is brain protective in the presence of KATP openers.More and more researches show that KATP channel is activated in pathological conditions,such as cerebral hypoxia and ischemia,resulting in the massive outflow of potassium current and cell membrane hyperpolarization.The consequent decrease in the inflow of sodium and calcium currents is reduced,which prevents or minimizes calcium overload,lowers energy consumption,reduces the release of excitory amino acids and oxygen free radicals,and protects brain cells.

关 键 词：三磷酸腺苷敏感性钾通道 开放剂 保护作用 

分 类 号：R614[医药卫生—麻醉学]