加快非去极化肌松药起效的研究进展  

Progress on Methods of Shortening the Onset of Oon-depolarizing Muscle Relaxants

作　　者：韩传钢[1] 陈益[1] 王力甚[1] 

机构地区：[1]湖北省荆州市中心医院麻醉科,湖北荆州430040

出　　处：《医学综述》2011年第7期1075-1078,共4页Medical Recapitulate

摘　　要：非去极化肌松药是快速序贯诱导复合用药一个重要组成部分。全麻诱导期间呼吸道保护性反射减弱,极容易发生缺氧、反流误吸等并发症,应尽快行气管插管控制呼吸道,因此,肌松药起效的快慢对麻醉诱导期的安全至关重要。临床上缩短非去极化肌松药起效时间常用的方法包括:增大剂量、预注法、分次注射法和限时法等,每种方法各有优缺点,在此将对这些加速非去极化肌松药起效方法的相关研究进行综述。Non-depolarizing muscle relaxants（NMR） are given as part of rapid sequence induction.It is very susceptible to hypoxia and aspiration,as the airway protective reflex is decreased during the induction of anesthesia.In order to prevent aspiration,the time interval between the induction of anesthesia and the tracheal intubation should be kept as short as possible.The methods,including administration of large doses,priming principle,timing principle,combination of drugs,and development of a new NMR,are applied to decrease the onset time of NMR.Each method has its advantages and disadvantages.This review summarizes these methods that shorten the onset of non-depolarizing muscle relaxants.

关 键 词：非去极化 肌松药 起效时间 

分 类 号：R614[医药卫生—麻醉学]