慢性充血性心衰者血清生长激素与肿瘤坏死因子水平变化及意义  

Changes of serum growth hormone and tumor necrosis factor levels and their clinical significance in patients with chronic congestive heart failure

作　　者：张英萍[1] 李艳丽[1] 

机构地区：[1]佳木斯市中心医院心内科,黑龙江佳木斯154002

出　　处：《心血管康复医学杂志》2011年第2期139-140,共2页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的：研究慢性充血性心力衰竭（CHF）患者血清生长激素（GH）及肿瘤坏死因子α（TNF-α）的含量变化及意义。方法：应用放射免疫法测定36例CHF患者及30例健康体检者的血清GH及TNF-α含量,并比较两组的含量。结果：与健康体检者比较,CHF患者血清GH[（1.91±0.67）ng/ml∶（4.87±1.64）ng/ml]、TNF-α[（19.23±6.78）fmol/ml∶（44.64±19.48）fmol/ml]浓度显著升高（P〈0.01）;TNF-α水平随心功能分级增高而增高,心衰各组间差异显著（P〈0.05~0.01）。结论：结果提示血清生长激素和肿瘤坏死因子α均与心衰的发生和发展有关,肿瘤坏死因子α与心功能状态有关。Objective：To study changes of serum growth hormone（GH） and tumor necrosis factor-alpha（TNF-α） levels and their significance in patients with chronic congestive heart failure（CHF）.Methods：Radioimmunoassay was used to measure levels of serum GH and TNF-α in 36 patients with CHF and 30 normal controls,and levels of GH and TNF-α were compared between two groups.Results：Compared with normal controls,levels of serum GH [（1.91±0.67）ng/ml vs.（4.87±1.64）ng/ml]and TNF-α [（19.23±6.78） fmol/ml vs.（44.64±19.48） fmol/ml] significantly increased in patients with CHF（P0.01 both）.The level of TNF-α increased as cardiac function class increased and it showed significant difference among all groups of heart failure（P0.05~0.01）.Conclusion：The results suggest that both serum growth hormone and tumor necrosis factor-alpha correlated with occurrence and development of heart failure,and level of tumor necrosis factor-alpha is associated with cardiac function state.

关 键 词：心力衰竭 充血性 肿瘤坏死因子Α 人生长激素 

分 类 号：R587.1[医药卫生—内分泌]