联萘酚键合手性固定相的合成与应用  

Synthesis and application of binaphthol-bonded chiral stationary phase

作　　者：刘国庆[1] 詹峰萍[1] 林爱清[1] 郭东仁[1] 翁文[1] 

机构地区：[1]漳州师范学院化学与环境科学系,福建漳州363000

出　　处：《应用化工》2011年第3期402-403,407,共3页Applied Chemical Industry

基　　金：国家自然科学基金项目(20705031)

摘　　要：通过硅烷偶联剂将对映纯联萘酚键合到球形硅胶上制得手性固定相,元素分析表明,该固定相中C和H的含量分别为7.33%和0.88%,对应键合量为0.212 mmol/g。填装后考察其在7个联萘化合物手性拆分中的应用,自制手性柱对联萘酚和溴代联萘酚显示出较好的手性识别能力,分离因子分别为1.177和1.193,但该固定相的键合量和柱效还需进一步的提高。Enantiomerically pure binaphthol was bonded onto spherical silica gel with a silane coupling agent KH560.The obtained chiral stationary phase was submitted for element analysis.The cotent（w/w） of carbon and hydrogen was 7.33% and 0.88%,respectively.The corresponding bonded amount was0.212 mmol/g.The chiral stationary phase was packed by slurrying method.Then evaluation of this chiral column for the enantioseparation of seven binaphthyl compounds was presented.The separation factors for binaphthol and bromo-substituted binaphthol were 1.177 and 1.193,respectively.The bonded amount and column efficiency need to be improved further.

关 键 词：液相色谱 联萘酚 手性固定相 手性拆分 

分 类 号：O657.7[理学—分析化学]