大黄黄连泻心汤、理中丸对四种模型胃溃疡寒热证大鼠血清PAF含量的影响  

The Effect of Dahuang Huanglian Xiexin Decoction and Lizhong Pills on PAF Contents in Serum on Four Kinds of Gastric Ulcer Models Combined with Cold or Heat Syndrome Rats

作　　者：毕珺辉[1] 李冀[1] 谢田[1] 赵雪莹[1] 于海[1] 蒋蕾[1] 赵伟国[1] 柴剑波[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药学报》2011年第2期51-55,共5页Acta Chinese Medicine and Pharmacology

基　　金："十一五"国家科技支撑计划项目(编号:2006BAI08B04-03);黑龙江省中医药管理局项目(编号:ZHY10-W01);哈尔滨市青年创新人才基金(编号:2009RFQXS003)

摘　　要：目的:探讨消炎痛型、水浸应激型、幽门结扎型和醋酸涂抹型胃溃疡中医寒热证模型的形成机制及寒热方剂对胃溃疡寒热证模型的基本作用机理和方证相应的客观规律。方法:采用寒热因素结合四种模型,分别建立大鼠胃溃疡寒、热证模型,用酶联免疫法检测大黄黄连泻心汤、理中丸对受试大鼠血清PAF含量的影响。结果:各模型组与空白组比较血清PAF含量显著升高(P<0.05或P<0.01);大黄黄连泻心汤可显著降低热性溃疡组大鼠血清PAF的含量,理中丸可降低寒性溃疡组大鼠血清PAF的含量(P<0.05或P<0.01)。结论:通过"方证相应"理论验证了"病证结合"的胃溃疡寒热模型复制成功,大黄黄连泻心汤对热性胃溃疡、理中丸对寒性胃溃疡的治疗作用,可通过降低大鼠血清PAF的含量而实现。Objective：To explore the forming mechanism of gastric ulcer model induced by indomethacin,water immersion stress,pylorus deligation and smearing acetic acid combined with cold or heat syndrome.And to observe the basic and objective regularity of ＂formula-syndrome corresponding＂ of cold or heat formula on gastric ulcer model combined with cold or heat syndrome.Methods： Adopting cold or heat factors combined four methods to establish gastric ulcer model combined with cold and heat syndrome.Using ELISA to detect the influence of Dahuang Huanglian Xiexin Decoction and Lizhong Pill on PAF contents in gastro-tissue.Results：Compared to the blank group,the contents of PAF in stomach-tissue of every modle-group increased remarkably.（P0.05 or P0.01）Dahuang Huanglian Xiexin Decoction can decrease the contents of PAF in stomach-tissue of heat-ulcer group obviously.Lizhong Pill can decrease the contents of PAF in stomach-tissue of cold-ulcer group strikingly.（P0.05 or P0.01） Conclusions：On the basis of the theory of ＂formula-syndrome corresponding＂,verifying the success of duplicating ＂disease-syndrome combination model＂,that is gastric ulcer model combined with cold and heat syndrome.The therapeutic action of Dahuang Huanglian Xiexin Decoction on heat-gastric ulcer,or Lizhong Pill on cold-gastric ulcer both can be achieved by decreasing the contents of PAF in stomach-tissue.

关 键 词：大黄黄连泻心汤 理中丸 寒热证 胃溃疡 PAF 

分 类 号：R285.5[医药卫生—中药学]