护心胶囊治疗老年慢性心力衰竭的临床研究  

The Efficacy of Huxin Capsule in the Treatment of Chronic Heart Failure of the Aged

作　　者：潘宇[1] 刘东方[2] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中医药学报》2011年第2期116-118,共3页Acta Chinese Medicine and Pharmacology

摘　　要：目的:观察护心胶囊治疗老年慢性心力衰竭的临床疗效及安全性。方法:106例老年CHF患者随机分为两组,对照组46例,予西医常规治疗,地高辛用量0.125mg/d;治疗组60例,在对照组基础上地高辛用量改为0.0625mg/d,并予护心胶囊,每次5粒,每日3次口服。两组均1个月为1个疗程,观察临床疗效及心功能指标变化。结果:治疗组总有效率92.6%,对照组74.1%。两组比较差异有统计学意义(P<0.05);治疗组心功能参数心输出量(CO)、每搏输出量(SV)、射血分数(LVEF)及舒张晚期与舒张早期充盈速度比(A/E)等好转情况均明显优于对照组(P<0.05),对照组发生洋地黄中毒4例,治疗组无不良事件发生。结论:护心胶囊治疗老年人心衰安全有效,可减少地高辛用量,减少洋地黄中毒的发生。Objective：To observe the clinical effect and security of huxin capsule in treating heart failure of the aged.Methods：106 patients of the aged with heart failure were randomly divided into two groups.46 patients in control group were treated by routine treatment of western medicine,the amount of digoxin 0.125mg/d.60 patients in treatment group were treated by combination of routine therapy,the amount of digoxin 0.0625mg/d,and huxin capsule,5 pills,three times a day.The course was 30 days in two groups.The changes of overall curative effect and heart function of heart failure patients were observed.Results： The total effective rate was 92.6% in treatment group and 74.1% in control group.There was a significant difference between two groups on total effective rate（P0.05）.The improvement of heart function including cardiac output（CO）,stroke volume（SV）,LVEF and A/E ratio in treatment group were superior to those in the control group（P0.05）.The control group had 3 cases of digitalis toxicity,while the treatment group had no adverse events.Conclusion：Huxin capsule was a safe and effective medicine in the treatment of heart failure of the aged.It can reduce the amount of digoxin and reduce the incidence of digoxin toxicity.

关 键 词：地高辛 老年人 护心胶囊 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]