血清中葡萄糖6磷酸异构酶阳性的中国汉族类风湿关节炎的临床特点  

Clinical significance of glucose-6-phosphate isomerase in Chinese Han patients with rheumatoid arthritis

作　　者：李博 何伟珍[1] 叶志中[1] 孔卫红[1] 陈雅硕[1] 谢燕[1] 李剑松 张丽君[1] 庄俊汉 

机构地区：[1]深圳市第四人民医院香蜜湖风湿病分院广东医学院深圳风湿病学研究所,广东深圳518040

出　　处：《海南医学》2011年第8期5-6,共2页Hainan Medical Journal

基　　金：深圳市医学重点学科建设基金资助项目(编号:2005C10);深圳市科技计划项目(医疗卫生类)(编号:200903207)

摘　　要：目的探讨血清中葡萄糖6磷酸异构酶(GPI)阳性的中国汉族类风湿关节炎(RA)的临床特点。方法用酶联免疫吸收法(ELISA)在283例中国汉族RA患者中对GPI进行了测定,并分析GPI与RA临床表现和其他辅助检查结果之间的关系。结果 GPI在中国汉族RA患者中的阳性率为83.04%,与GPI阴性的RA患者相比,GPI阳性的RA患者的起病年龄较轻[(39±15)岁vs(51±18)岁,P<0.05)],28处关节疾病活动度积分(DAS28)较高[(3.772±0.281)分vs(2.783±0.564)分,P<0.05)]。结论 GPI在中国汉族RA患者的阳性率较高,有助于RA的筛查。血清中GPI阳性的RA患者的起病年龄相对较轻,病情活动性较高。Objective To explore the clinical significance of glucose-6-phosphate isomerase（GPI） in Chinese Han patients with rheumatoid arthritis（RA）.Methods Serum samples obtained from 283 Chinese Han RA patients was assayed for glucose-6-phosphate isomerase by ELISA and the relationship between the GPI and the disease activity was studied.Results Prevalence of GPI was 80.04% in Chinese Han RA patients,and the younger age and higher Disease activity score（DSA28） were found in GPI-positive group than those in GPI-negative group.Conclusion GPI was helpful for diagnosis of RA in Chinese Han population.The GPI-positive RA patients were often relatively younger and had higher disease activity.

关 键 词：葡萄糖6磷酸异构酶 类风湿关节炎 类风湿因子 

分 类 号：R593.21[医药卫生—内科学]