苯巴比妥负荷量分次给药治疗新生儿缺氧缺血性脑病71例疗效观察  

Efficacy of phenobarbital semi-dose loading in treatment of neonatal hypoxic ischemic encephalopathy

作　　者：陈丽珠[1] 陈永传[2] 盛丽萍[1] 陈永倖[3] 

机构地区：[1]海南省第二人民医院儿科,海南五指山572200 [2]北京和睦家医院检验科,北京100016 [3]海南省人民医院呼吸内科,海南海口570311

出　　处：《海南医学》2011年第8期89-90,共2页Hainan Medical Journal

摘　　要：目的观察苯巴比妥负荷量分次给药治疗新生儿缺氧缺血性脑病(NHIE)的疗效。方法回顾性总结了71例NHIE的临床资料,所有患儿均采用分次给予苯巴比妥负荷量(20 mg·kg-1·d-1半量)进行治疗。结果 71例患儿中69例(97.2%)得到较好的治疗效果,2例分别因合并中度硬肿及肺出血,呼吸衰竭死亡。结论苯巴比妥负荷量分次给药能较好的控制惊厥,起到治疗NHIE的作用,并且不会引起呼吸抑制。Objective To observe the efficacy of phenobarbital semi-dose loading neonate with hypoxic ischemic encephalopathy（NHIE）.Methods Retrospectively analyzed the clinical datas of 71 patients with NHIE;all the patients were given phenobarbital with fractional loading for treatment.Results 69 patients（97.2%） of total 71 got better treatment,2 patients were death because of respiratory failure.Conclusion Phenobarbital semi-dose loading can better control the seizures,playing a role in the treatment of NHIE,and will not cause respiratory depression.

关 键 词：苯巴比妥 新生儿缺氧缺血性脑病 疗效 

分 类 号：R722.1[医药卫生—儿科]