Livin和Bcl-2在喉鳞状细胞癌的表达及相关性研究  

The expressions of livin in laryngeal squamous cell carcinoma and its correlation with Bcl-2

作　　者：刘守洲[1] 林立强[2] 王孝[1] 孙艳艳[3] 韩在文[4] 

机构地区：[1]潍坊医学院耳鼻喉科教研室,山东潍坊261042 [2]临沂市人民医院,山东临沂276000 [3]威海市立医院,山东威海264200 [4]潍坊医学院附属潍坊市人民医院,山东潍坊261000

出　　处：《济宁医学院学报》2011年第2期90-92,共3页Journal of Jining Medical University

摘　　要：目的探讨Livin和Bcl-2蛋白在喉鳞状细胞癌(简称喉鳞癌)组织中的表达以及其相关性。方法采用免疫组化法检测Livin和Bcl-2在喉癌组织和正常喉黏膜组织中的表达。结果喉鳞癌组织中Livin阳性率77.5%,Bcl-2阳性率72.5%,与正常喉粘膜组织比较其差异有统计学意义(P<0.05)。Livin蛋白的表达与喉鳞癌的TNM分期及有无淋巴结转移有关(P<0.05),与患者年龄、性别和组织学分级比较差异无统计学意义(P>0.05)。在喉鳞癌组织中Livin和Bcl-2蛋白的表达呈正相关(r=0.339,P<0.05)。结论 Livin的高表达提示其参与了喉鳞癌的发生、发展及转移。Livin与Bcl-2在喉鳞癌癌变中发挥了协同作用。Objective To explore the expression of Livin and Bcl-2 and the interrelation of Livin and Bcl-2 in Laryngeal Squamous Cell Carcinoma（LSCC）tissue.Methods The expression of Livin and Bcl-2 was examined by immunohistochemical staining in LSCC tissue and normal laryngeal mucosa tissue.Results Compared with those of normal laryngeal mucosa tissues,the positive rate of Livin in LSCC tissues was significantly higher（P0.05）.Compared with those of normal laryngeal mucosa tissues,the positive rate of Bcl-2 in LSCC tissues was significantly higher（P0.05）.The expression of Livin was closely related to TNM staging and lymphatic metastasis of LSCC,but the expressions of Livin had no relationship with age,sex and histological grade（P0.05）.The expressions of Livin in LSCC were positively related to the expressions of Bcl-2 in LSCC（r=0.339,P0.05）.Conclusion The overexpressions of Livin may play an important role in process of the pathogenesis,development and transfer of LSCC.The overexpressions of Livin and Bcl-2 may play synergetic roles in process of carcinogenesis of LSCC.

关 键 词：凋亡抑制蛋白 鳞状细胞癌 LIVIN BCL-2 免疫组织化学 

分 类 号：R766.5[医药卫生—耳鼻咽喉科]