真性红细胞增多症患者红细胞免疫功能检测  

Detection of erythrocyte immune function of patients with Polycythemia Vera

作　　者：周建伟[1] 孔翠[1] 刘凌云[1] 刘海峰[1] 史硕[1] 

机构地区：[1]济宁医学院附属医院,山东济宁272029

出　　处：《济宁医学院学报》2011年第2期99-101,共3页Journal of Jining Medical University

摘　　要：目的研究真性红细胞增多症患者血清循环免疫复合物水平及红细胞免疫功能状态。方法 ELISA法检测真性红细胞增多症患者血清循环免疫复合物浓度,参照文献报道方法测定红细胞免疫功能,直线回归分析血清循环免疫复合物与红细胞免疫功能各指标间的相关性。结果与正常人比较,真性红细胞增多症患者红细胞受体花环形成率、红细胞花环促进率、红细胞促淋巴细胞增殖率显著降低(P<0.05),红细胞免疫复合物花环形成率、红细胞花环抑制率则明显增高(P<0.05),血清循环免疫复合物浓度亦明显增高(P<0.01),且与除红细胞促淋巴细胞增殖率以外的红细胞免疫功能诸指标均具有相关关系。结论真性红细胞增多症患者红细胞免疫功能低下,降低患者血清循环免疫复合物水平可能有助于免疫系统功能恢复和病情改善。Objective To explore the level of circulating immune complex（CIC） in serum and erythrocyte immune function（EIF） in patients with Polycythemia Vera（PV）.Methods The concentration of CIC in patients with PV was measured with ELISA and EIF was analyzed using in the references respectively,and the correlation was further analyzed between them.Results Compared to healthy adults the rate of red blood cell C3b receptor rosette（RBC-C3bRR）,rosette formation enhancing rate（RFER） and lymphocyte proliferation rate（LPR）by red blood cell all decreased significantly（P0.05）,red blood cell immune complex rosette（RBC-ICR） and rosette forming inhibitory rate（RFIR） increased（P0.05）significantly.The concentration of CIC was also higher than healthy adults（P0.01）and it was correlated with the measurements of EIF except LPR.Conclusion The level of EIF is low in patients with PV and degraduation of CIC will help to recover the function of immune system and alleviate the illness.

关 键 词：真性红细胞增多症 循环免疫复合物 红细胞免疫功能 

分 类 号：R446.63[医药卫生—诊断学] R555[医药卫生—临床医学]