α_2-抗纤溶酶与静脉血栓栓塞症的研究  

The role of 2-antiplasmin in venous thrombolism

作　　者：张玲[1] 侯丽虹[2] 刘秀娥[2] 李参[1] 黄灿[1] 李凌飞[1] 

机构地区：[1]山西医科大学研究生院,太原030001 [2]山西医科大学第二医院血液科

出　　处：《中国药物与临床》2011年第4期368-370,共3页Chinese Remedies & Clinics

基　　金：山西省自然科学基金(2010011050-5)

摘　　要：目的探讨α2-抗纤溶酶(α2-AP)的活性与静脉血栓栓塞症(VTE)的关系。方法选择VTE患者102例,包括深静脉血栓形成(DVT)74例[彩色多普勒超声和(或)静脉造影确诊]和肺血栓栓塞症(PTE)28例;健康对照组95例。采用全自动血凝分析仪检测α2-AP活性(α2-AP:Ac)。采用两独立样本的t检验,分析α2-AP:Ac对VTE血栓形成的影响;采用Logistic回归进行VTE危险因素评估。结果在VTE组中α2-AP:Ac较对照组明显增高,差异有统计学意义(P<0.05)。Logistic回归分析表明α2-AP:Ac增高是VTE的危险因素(P<0.05)。结论 VTE患者血浆α2-AP:Ac明显增高,可能是VTE发病的危险因素之一。Objective To investigate the relationship between 2-Antiplasmin activity and venous thromboembolism（VTE）.Methods 102 cases of VTE confirmed by ultrasonography and/or venography,including 74 of deep vein thrombosis（DVT） and 28 of pulmonary thromboemlism（PTE）,along with 95 normal controls,were measured for 2-antiplasmin activity（2-AP Ac） using one-stage clotting assay.Independent t-test was employed to investigate the effects of 2-AP Ac on development of VTE,and two-variate Logistic regression to evaluate the risk factors for VTE.Results The plasma level of 2-AP Ac was elevated significantly in patients with VTE than in controls（P0.05）.Logistic regression showed that higher plasma level of 2-AP Ac was a risk factor for VTE（P0.05）.Conclusion VTE patients may present with obviously high level of 2-AP Ac level,which may be one of VTE risk factors.

关 键 词：静脉血栓形成 肺栓塞 Α2-抗纤溶酶 纤溶酶 

分 类 号：R543.6[医药卫生—心血管疾病]