不同病因急性弥漫性血管内凝血临床特点及指标观察  

Clinical Characteristics and Indicators Observation of Patients with Different Causes of Acute Disseminated Intravascular Coagulation

作　　者：于飞[1] 朱崇晖 

机构地区：[1]青岛市第八人民医院,山东青岛266100

出　　处：《中国医药指南》2011年第12期9-11,共3页Guide of China Medicine

摘　　要：目的探讨感染、急性白血病、病理产科3种不同病因急性弥漫性血管内凝血(DIC)临床特点及血小板(PLT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fg)、凝血酶时间(TT)、硫酸鱼精蛋白副凝(3P)试验、D-二聚体(D-D)阳性率在不同病因DIC中有无差异。方法回顾性分析青岛市第八人民医院2006年11月至2010年11月收治住院的71例以感染、急性白血病、病理产科为基础病的DIC患者的临床资料,对比3种不同病因DIC患者临床出血程度、休克、重要器官损害、微血管溶血表现及PLT、PT、APTT、Fg、TT、3P试验、D-二聚体阳性率。结果 3组患者在出血程度、休克发生率、重要器官损害发生率、疗效、病死率、APTT阳性率方面比较,差异有统计学意义(P<0.05),在PLT、PT、Fg、TT、3P试验、D-二聚体阳性率方面,3组比较差异无统计学意义(P>0.05)。组间两两比较结果显示,感染组与急性白血病组、病理产科组在出血程度、重要器官损害发生率、疗效、病死率方面比较有统计学意义(P<0.05);急性白血病组与感染组、病理产科组在休克发生率方面比较有统计学意义(P<0.01);急性白血病组和感染组在APTT阳性率方面比较,差异有统计学意义(P<0.01)。结论病理产科相关DIC和急性白血病相关DIC临床出血重,器官损害较少,预后较好。感染相关DIC出现休克、器官损害多见,疗效、预后差、病死率高。Objective To investigate the infection,acute leukemia,the pathological cause of acute obstetrical DIC 3 different clinical characteristics and platelet count（PLT）,prothrombin time（PT）,activated partial thromboplastin time（APTT）,fibrinogen（Fg）,Vice-condensing protamine sulfate（3P） test,thrombin time（TT）,D-dimer positive rate of DIC in the presence or absence of differences between different causes.MethodsA retrospective analysis of our hospital from November 2006 to November 2010 to 71 cases admitted to hospital infection,acute leukemia,the disease pathology obstetric DIC-based clinical data,compared to 3 different causes of clinical bleeding in patients with DIC degree Shock,major organ damage,micro-vascular hemolytic performance and positive rate of PLT,PT,APTT,Fg,TT,3P,D-dimer.ResultsThe three groups of patients in the degree of bleeding,shock rate,the incidence of major organ damage,efficacy,mortality,APTT-positive rate,the difference was statistically significant（P0.05）,the positive rate of PLT,PT,Fg,TT,3P,DD in the three groups were no significant difference（P0.05）.Pair wise comparison between groups showed that infection and acute leukemia group,the pathological extent of obstetric hemorrhage group,the incidence of major organ damage,efficacy,mortality was statistically significant（P0.05）;acute leukemia group and infected group Pathological obstetric group compared the incidence of shock was significant（P0.01）;acute leukemia group and infected group compared the positive rate in the APTT,the difference was statistically significant（P0.01）.ConclusionThe pathology associated obstetric DIC and acute leukemia clinical bleeding heavy,less organ damage,the prognosis is good.DIC infection,shock,organ damage common,efficacy,poor prognosis and high mortality.

关 键 词：急性弥漫性血管内凝血 临床特点 观察指标 

分 类 号：R554.8[医药卫生—血液循环系统疾病]