固定剂量复合剂在流动人口与户籍人口结核病防治中的效果比较  

Effect comparison of fixed-dose combinations in tuberculosis control between floating population and local residents

作　　者：于梅[1] 董红军[1] 赵敏捷[1] 贺天峰[1] 顾永权 杜飞行[3] 殷立平[4] 

机构地区：[1]浙江省宁波市疾病预防控制中心,浙江宁波315010 [2]浙江省余姚市疾病预防控制中心,浙江余姚315400 [3]浙江省奉化市疾病预防控制中心,浙江奉化315500 [4]浙江省象山县疾病预防控制中心,浙江象山315700

出　　处：《中国农村卫生事业管理》2011年第4期407-409,共3页Chinese Rural Health Service Administration

基　　金：宁波市科技局基金资助项目(200801C010027)

摘　　要：目的:研究国产固定剂量复合剂(FDC)在流动人口和户籍人口中的结核病防治效果。方法:将2008年3月1日至2009年3月1日发现的肺结核患者,按户口类型分为流动人口和户籍人口两组,在强化期和继续期分别使用HRZE(R 150mg、H 75mg、Z 400mg、E 275mg)和HR(H 100mg、R 150mg H75mg、R 150mg)进行治疗,观察两组治疗转归、痰菌阴转率、服药后血常规的变化、药物的可接受性等情况。结果:在流动人口组和户籍人口组中,涂阳肺结核患者治愈率分别为79.17%和83.52%,第2、3、5、6月末痰菌阴转率流动人口组分别为85.42%、93.75%、93.75%、95.83%,户籍人口组分别为90.11%、92.31%、97.80%、95.60%,差异无统计学意义(P>0.05)。不良反应率为9.47%和19.88%,差异有统计学意义(χ2=4.85,P=0.0277);药物的可接受性上流动人口组高于户籍人口组。在药物口感、药片数量、药片粘喉等问题上两组患者回答结果差异均无统计学意义。结论:国产固定剂量复合剂在流动人口与户籍人口中的治疗效果相同,但在流动人口中不良反应率低,更易被患者接受,应该进一步在流动人口中推广应用。Objective To study the prevention and control effect of domestic fixed--dose combinations （FDC） on tuberculosis among floating population and local residents. Methods Tuberculosis cases detected from March 1,2008 to March 1,2009 were divided into two groups ,floating population group and local residents group. HRZE（R 150mg,H 75mg,Z 400mg,E 275rag）and HR（H 100mg,R 150rag 75mg,R 150rag）were used to treat tuberculosis in intensive phase and continuation phase respectively. Many conditions were observed including treatment conversion, sputum negative conversion ratio ,blood routine change after taking medicine ,drug acceptability ,and so on in the two groups. ResultsIn floating population group and local residents group, the cure rate of smear positive tuberculosis patients were 79. 17% and 83. 52%//00, the sputum negative conversion rates at the end of 2nd,3rd,5th and 6th month in the floating population group were 85.42% ,93.75% ,93.75% and 95.83% respectively,and those in the local residents group were 90. 11%, 92. 31%, 97. 80% ,and 95.60% respectively. There was no significant difference between the two groups （P〉0. 05）. The rate of adverse reactions in floating population group （9.47%） was significantly lower than that in the local residents group （19.88%）. Drug acceptability of the floating population group was higher than that of the local residents group. The differences of the answers between the two groups patients in medicine taste, number of pills ,pills＇s viscosty,etc were insignificant. Conclusion The domestic FDC show similar treatment outcome in two groups, but it has lower adverse reaction rates and is more acceptable in floating population group, which should be further expanded in floating population group.

关 键 词：肺结核 固定剂量复合剂 预防与控制 流动人口 

分 类 号：R52[医药卫生—内科学]