血浆五聚素3与冠心病及冠脉病变严重程度的相关性研究  

Study on the relationship between the plasma pentraxin 3 and coronary artery diseases,and the severity of coronary artery lesions

作　　者：王强[1] 孙建辉[1] 王梦非[1] 戴贵军[1] 

机构地区：[1]苏州大学附属第三医院心内科,江苏常州213003

出　　处：《现代医学》2011年第2期134-138,共5页Modern Medical Journal

摘　　要：目的:探讨血浆五聚素3(PTX3)与冠心病发生、发展的相关性,并根据冠脉造影了解其与冠脉严重程度是否相关。方法:100例受试者分为正常对照组20例,稳定型心绞痛(SAP)组20例,不稳定型心绞痛(UA)组30例,急性心肌梗死(AMI)组30例,冠心病3组患者均行冠脉造影检查,并分别检测各组入院第2天血浆PTX3、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)和超敏C反应蛋白(hs-CRP)等生化指标,并进行比较。冠心病3组患者按Gensini标准对冠状动脉病变程度进行积分,了解PTX3水平是否与冠状动脉严重程度相关。结果:SAP组与正常对照组之间PTX3水平差异无统计学意义(P>0.05),UA组和AMI组PTX3水平高于SAP组和正常对照组(P<0.05)。UA组与AMI组之间PTX3水平差异无统计学意义(P>0.05)。经Spearman相关分析表明,冠状动脉病变严重程度与PTX3水平无明显相关性,而血浆脂质成分指标与冠脉病变程度的相关性似乎更加密切。结论:PTX3水平与冠心病临床分型的轻重程度有相关性,而与冠状动脉严重程度无明显相关性。Objective：To evaluate the correlation between pentraxin 3 levels and the occurrence,evolution of coronary artery diseases,and explore the relationship between pentraxin 3 levels and coronary artery lesion according to angiography.Methods：100 subjects were divided into normal group（n=20）,SAP group（n=20）,UA group（n=30） and AMI group（n=30）.The three groups of coronary artery disease underwent angiography.The pentraxin 3 levels of each group as well as TG,TC,LDL-C,hs-CRP and FBG were detected on the second day of admission.According to Gensini standard,criteria points were calculated to the three groups of coronary artery diseases were calculated to understand whether the PTX3 levels correlated with the severity of coronary artery lesions.Result：The different PTX3 levels between the SAP group and normal group were not statistically significant（P〈0.05）.The PTX3 levels in UAP group and AMI group were significantly higher than those of the other two groups（P〈0.05）.The different PTX3 levels between the UA group and AMI group were also not statistically significant（P〈0.05）.The spearman correlation analysis showed that there was not a significant correlation between PTX3 levels and the severity of coronary artery lesions.But the plasma lipid and the coronary artery lesion appeared to be more closely related.Conclusion：The PTX3 levels were correlated with severity of clinical classification in coronary artery disease,but not significantly correlated with the severity of coronary artery lesions itself.

关 键 词：血浆五聚素3 冠心病 冠状动脉造影 

分 类 号：R541.4[医药卫生—心血管疾病]